| Bioglass (R) stimulation of embryonic long-bones in altered loading environments. | |
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MedLine Citation:
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PMID: 12650182 Owner: NASA Status: MEDLINE |
Abstract/OtherAbstract:
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The 45S5 composition glass (Bioglass (R), USBiomaterials, USA) contains 45 wt% SiO2, 24.5 wt% CaO, 24.5 wt% Na2O and 6 wt% P2O5. It is a low SiO2 (45 wt%) and a high Na2O content glass that results in rapid ion exchange when exposed to physiological solutions. The change in local solution chemistry results in rapid nucleation (1-3 hours exposure) and subsequent crystallisation of hydroxyl-carbonate-apatite (HCA) identical to naturally occurring bone mineral within a hydrated SiO2-rich layer developed on the glass surface. During HCA layer formation, proteins and other growth factors are absorbed into the layer. The synthetic bone mineral layer bonds to collagen, produced by the host tissue, which leads to a strong interfacial bond that is stronger than the host tissue (hard or soft) (Hench and West. 1996). In this study we show that the chemical effects responsible for enhanced bone cell proliferation and differentiation found in-vitro and in-vivo with Bioglass (R) may be sufficient to prevent the demineralisation of bone tissue that occurs as a result of ageing or exposure to a low loading environment i.e. implant/tissue stress-shielding, space-flight. |
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Authors:
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J Maroothynaden; L L Hench |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology Volume: 8 ISSN: 1077-9248 ISO Abbreviation: J Gravit Physiol Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2003-03-21 Completed Date: 2003-09-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9437868 Medline TA: J Gravit Physiol Country: United States |
Other Details:
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Languages: eng Pagination: P79-80 Citation Subset: S |
Affiliation:
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Centre for Tissue Regeneration and Repair, Imperial College, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials / pharmacology* Calcification, Physiologic / drug effects, physiology* Calcium / metabolism Ceramics / pharmacology* Culture Techniques Femur / drug effects*, embryology, metabolism Mice Rotation Sodium / metabolism Weightlessness Simulation* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Bioglass; 0/Ceramics; 7440-23-5/Sodium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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