Document Detail

Biogenic amine metabolites in human CSF after hypoxia due to cardiac arrest.
MedLine Citation:
PMID:  2476907     Owner:  NLM     Status:  MEDLINE    
The concentrations of 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxyindole-3-acetic acid (5-HIAA) and homovanillic acid (HVA) were determined in CSF of patients with hypoxia due to circulatory arrest. Patients were divided into neurologically disabled and recovered according to the Glasgow Coma Scale. CSF was collected 4, 28, 76 and 172 h after commencement of resuscitation and once from control patients subjected to spinal anaesthesia. The initial concentrations of MHPG, 5-HIAA and HVA were significantly higher in a subgroup of neurologically disabled patients who died within 76 h. In recovered patients the concentration of MHPG declined with time to the value of the control group, whereas it increased in neurologically disabled patients. In the latter group the concentration of 5-HIAA also showed an increase with time, whereas in recovered patients it declined after an initial rise. It is concluded that high concentrations of MHPG, 5-HIAA and HVA in CSF may be prognostic for hypoxic brain injury after cardiac arrest.
J Odink; J Kärkelä; J T Thissen; K M Marnela
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  80     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-10-23     Completed Date:  1989-10-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  6-11     Citation Subset:  IM    
Department of Clinical Biochemistry, TNO-CIVO Toxicology and Nutrition Institute, Zeist, The Netherlands.
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MeSH Terms
Aged, 80 and over
Anoxia / cerebrospinal fluid*,  etiology
Biogenic Amines / cerebrospinal fluid
Glycols / cerebrospinal fluid*
Heart Arrest / complications*
Homovanillic Acid / cerebrospinal fluid*
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Methoxyhydroxyphenylglycol / cerebrospinal fluid*
Middle Aged
Reg. No./Substance:
0/Biogenic Amines; 0/Glycols; 306-08-1/Homovanillic Acid; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid

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