| Biogenesis of peroxisomes in fetal liver. | |
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MedLine Citation:
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PMID: 9408912 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peroxisomes are single membrane-limited cell organelles that are involved in numerous metabolic functions. Peroxisomes do not contain DNA; the matrix and membrane proteins are encoded by the nuclear genome. It is assumed that new peroxisomes are formed by division of existing organelles. The present article gives an overview of microscopic studies and recent unpublished results dealing with peroxisome biogenesis in mammalian fetal liver and presents data on peroxisomes in oocytes. Cytochemical (catalase and D-aminoacid oxidase activity) and immunocytochemical data in rat and human liver (antigens of catalase, the three peroxisomal beta-oxidation enzymes, alanine: glyoxylate aminotransferase, peroxisomal membrane proteins with molecular weights of 42 and 70 kDa) indicate that during embryonic and fetal development the peroxisomal population undergoes a differentiation with respect to the composition of the matrix and to the size and number of the organelles. In the youngest stages, rare and small peroxisomes are present, into which the matrix components are imported in a sequential way. The import seems asynchronous in peroxisomes of the same hepatocyte. The size and number of the peroxisomes increase during liver development. In rat and human liver, no morphological or immunocytochemical evidence for an elaborate network of interconnected peroxisomes ("reticulum") was found. Instead, peroxisomes presented as individual organelles, which occasionally show membrane extensions. The importance of the metabolic functions of peroxisomes in human liver is emphasized by the peroxisomal disorders. In the liver of affected fetuses, the microscopic features associated with the defect can already be recognized; i.e., either catalase containing peroxisomes are absent and catalase is localized in the cytoplasm (in fetuses affected with Zellweger syndrome or with infantile Refsum disease) or peroxisomes are present but they are abnormally enlarged (e.g., a fetus affected with acyl-CoA oxidase deficiency). In the quail ovary, numerous peroxisomes are observed in the oocyte and in the granulosa cells during follicle maturation, but not in the full-grown egg. Thus, the mechanism of peroxisome inheritance remains unresolved. |
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Authors:
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M Espeel; M Depreter; R Nardacci; K D'Herde; I Kerckaert; S Stefanini; F Roels |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Microscopy research and technique Volume: 39 ISSN: 1059-910X ISO Abbreviation: Microsc. Res. Tech. Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-02-03 Completed Date: 1998-02-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203012 Medline TA: Microsc Res Tech Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 453-66 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Embryology and Histology, University of Gent, Belgium. marc.espeel@rug.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Histocytochemistry Humans Immunohistochemistry Liver / embryology*, metabolism, ultrastructure Microbodies / metabolism*, ultrastructure Microscopy, Electron Oocytes / cytology, metabolism, ultrastructure Peroxisomal Disorders / metabolism Quail Rats |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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