Document Detail

Biofortification of plants with altered antioxidant content and composition: genetic engineering strategies.
MedLine Citation:
PMID:  22970850     Owner:  NLM     Status:  MEDLINE    
Antioxidants are protective molecules that neutralize reactive oxygen species and prevent oxidative damage to cellular components such as membranes, proteins and nucleic acids, therefore reducing the rate of cell death and hence the effects of ageing and ageing-related diseases. The fortification of food with antioxidants represents an overlap between two diverse environments, namely fortification of staple foods with essential nutrients that happen to have antioxidant properties (e.g. vitamins C and E) and the fortification of luxury foods with health-promoting but non-essential antioxidants such as flavonoids as part of the nutraceuticals/functional foods industry. Although processed foods can be artificially fortified with vitamins, minerals and nutraceuticals, a more sustainable approach is to introduce the traits for such health-promoting compounds at source, an approach known as biofortification. Regardless of the target compound, the same challenges arise when considering the biofortification of plants with antioxidants, that is the need to modulate endogenous metabolic pathways to increase the production of specific antioxidants without affecting plant growth and development and without collateral effects on other metabolic pathways. These challenges become even more intricate as we move from the engineering of individual pathways to several pathways simultaneously. In this review, we consider the state of the art in antioxidant biofortification and discuss the challenges that remain to be overcome in the development of nutritionally complete and health-promoting functional foods.
Changfu Zhu; Georgina Sanahuja; Dawei Yuan; Gemma Farré; Gemma Arjó; Judit Berman; Uxue Zorrilla-López; Raviraj Banakar; Chao Bai; Eduard Pérez-Massot; Ludovic Bassie; Teresa Capell; Paul Christou
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-09-13
Journal Detail:
Title:  Plant biotechnology journal     Volume:  11     ISSN:  1467-7652     ISO Abbreviation:  Plant Biotechnol. J.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-29     Completed Date:  2013-08-01     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  101201889     Medline TA:  Plant Biotechnol J     Country:  England    
Other Details:
Languages:  eng     Pagination:  129-41     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors Plant Biotechnology Journal © 2012 Society for Experimental Biology, Association of Applied Biologists and Blackwell Publishing Ltd.
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MeSH Terms
Antioxidants / metabolism*
Ascorbic Acid / biosynthesis
Carotenoids / biosynthesis
Crops, Agricultural / chemistry*,  genetics
Flavonoids / biosynthesis
Food, Fortified*
Functional Food
Genetic Engineering*
Health Food
Melatonin / biosynthesis
Nutritive Value
Plants, Genetically Modified / chemistry,  genetics
Ubiquinone / analogs & derivatives,  biosynthesis
Grant Support
232933//European Research Council
Reg. No./Substance:
0/Antioxidants; 0/Flavonoids; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10; 36-88-4/Carotenoids; JL5DK93RCL/Melatonin; PQ6CK8PD0R/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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