Document Detail


Biofilms in skin infections: Propionibacterium acnes and acne vulgaris.
MedLine Citation:
PMID:  18782032     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is generally accepted that many human infections are biofilm-related and that sessile (biofilm-grown) cells are highly resistant against antimicrobial agents. Propionibacterium acnes plays a role in the pathogenesis of acne vulgaris, a common disorder of the pilosebaceous follicles and it has been suggested that P. acnes cells residing within the follicles grow as a biofilm. Although P. acnes biofilms have not been observed directly in the pilosebaceous unit, the observation that P. acnes readily forms biofilm in vitro as well as on various medical devices in vivo, combined with the high resistance of sessile P. acnes cells and the increased production of particular virulence factors and qourum sensing molecules in sessile cells point in this direction. In addition, in vitro and in vivo biofilm formation has also been demonstrated for other microorganisms involved in skin diseases (including Staphylococcus aureus and Streptococcus pyogenes).
Authors:
T Coenye; K Honraet; B Rossel; H J Nelis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Infectious disorders drug targets     Volume:  8     ISSN:  1871-5265     ISO Abbreviation:  -     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-10     Completed Date:  2008-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101269158     Medline TA:  Infect Disord Drug Targets     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  156-9     Citation Subset:  IM    
Affiliation:
Laboratory for Pharmaceutical Microbiology, Ghent University, Ghent, Belgium, Oystershell NV, Drongen, Belgium. Tom.Coenye@UGent.be
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MeSH Terms
Descriptor/Qualifier:
Acne Vulgaris / microbiology*
Animals
Biofilms*
Drug Resistance, Bacterial
Humans
Propionibacterium acnes / growth & development*,  pathogenicity
Quorum Sensing
Sebaceous Glands / microbiology*
Virulence
Virulence Factors / metabolism
Chemical
Reg. No./Substance:
0/Virulence Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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