| Biofilms in chronic rhinosinusitis: systematic review and suggestions for future research. | |
| | |
MedLine Citation:
|
PMID: 21310099 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background:A biofilm is a community of micro-organisms encased within a self-produced, extracellular, polymeric substance. The role of biofilms as a major pathological aetiology in chronic rhinosinusitis would help explain the clinical manifestation of the disease.Objectives:To examine the current evidence, and to discuss possible future research directions, in relation to biofilms and chronic rhinosinusitis.Study design:Systematic literature review.Evaluation method:Two assessors independently undertook critical appraisal of the studies identified by the literature search. Significant findings were incorporated into this review. The primary outcome assessed was the presence of biofilm in human mucosal biopsy samples taken from patients with chronic rhinosinusitis, and from healthy controls.Results:We identified 11 studies examining biofilm formation in human mucosal biopsy samples taken from patients with chronic rhinosinusitis.Conclusion:It is unlikely that biofilms occur in every case of chronic rhinosinusitis; consequently, the significance of 'biofilm detection' in some series should be considered carefully. Several authors have argued strongly for the use of confocal scanning laser microscopy with fluorescent in situ hybridisation probes as the 'gold standard' for biofilm imaging. This imaging modality should be combined with further investigation of the microbiology of chronic rhinosinusitis, and of the efficacy of traditional culture techniques used for pathogen identification. |
| | |
Authors:
|
J Keir; L Pedelty; A C Swift |
Related Documents
:
|
22301009 - New concepts of science and medicine in science and technology studies and their releva... 21459589 - A phantom experiment for the evaluation of whole body exposure during bnct using cyclot... 19899149 - A new method to measure vaginal sensibility. 22368909 - Suicide bombing: a geopolitical perspective. 8982759 - Future directions for research on endometrial bleeding. 21418109 - Modern indoor climate research in denmark from 1962 to the early 1990s: an eyewitness r... 19076669 - Wise owls and professors: the role of older researchers in the review of the national s... 23478739 - What do reviewers look for in an original research article? 20848039 - Organocatalytic strategies for the asymmetric functionalization of indoles. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-11 |
Journal Detail:
|
Title: The Journal of laryngology and otology Volume: - ISSN: 1748-5460 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8706896 Medline TA: J Laryngol Otol Country: - |
Other Details:
|
Languages: ENG Pagination: 1-7 Citation Subset: - |
Affiliation:
|
Department of Otolaryngology, Wirral University Teaching Hospital NHS Trust, Upton, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Infected tracheocoele (acquired tracheal diverticulum): case report and literature review.
Next Document: Surfers' awareness of the preventability of 'surfer's ear' and use of water precautions.