| Biofilm formation on silicone tympanostomy tubes with polyvinylpyrrolidone coating. | |
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MedLine Citation:
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PMID: 21242541 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether biofilm formation on silicone tympanostomy tubes (TTs) is prevented by polyvinylpyrrolidone (PVP) coating. DESIGN: In vitro microbiologic study. SUBJECTS: Silicone TTs with and without a PVP coating. INTERVENTION: The TTs were exposed to blood or phosphate-buffered saline and cultured with Pseudomonas aeruginosa or Staphylococcus aureus. After 4 days, antibiotics were added to kill planktonic bacteria. Biofilm formation was assessed by quantitative bacterial counts and scanning electron microscopy. RESULTS: Human blood enhanced S aureus biofilm formation on TTs with and without PVP (P < .001). Staphylococcus aureus biofilm formation was similar on TTs with and without PVP coating. Pseudomonas aeruginosa biofilm formation was less on TTs with PVP coating after exposure to phosphate-buffered saline (P = .04), but this difference was not significant after blood exposure (P = .19). CONCLUSIONS: Polyvinylpyrrolidone coating of TTs imparts resistance to P aeruginosa biofilm formation. The clinical impact of PVP on TTs may be attenuated by exposure to blood, but this will require study in clinical trials. |
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Authors:
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Patrick J Antonelli; Edith M Sampson; Carolyn Ojano-Dirain |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of otolaryngology--head & neck surgery Volume: 137 ISSN: 1538-361X ISO Abbreviation: Arch. Otolaryngol. Head Neck Surg. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8603209 Medline TA: Arch Otolaryngol Head Neck Surg Country: United States |
Other Details:
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Languages: eng Pagination: 19-23 Citation Subset: AIM; IM |
Affiliation:
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Department of Otolaryngology, University of Florida, PO Box 100264, 1600 SW Archer Rd, Gainesville, FL 32610-0264. Patrick.Antonelli@ent.ufl.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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