| Biofilm formation and Toll-like receptor 2, Toll-like receptor 4, and NF-kappaB expression in sinus tissues of patients with chronic rhinosinusitis. | |
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MedLine Citation:
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PMID: 22182736 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Bacterial biofilm formation is associated with chronic rhinosinusitis (CRS). However, how bacterial biofilms are related to innate immune response in patients is poorly understood. The aim of this study was to evaluate the prevalence of biofilms in CRS patients and investigate the biofilm-relatedToll-like receptor (TLR) and downstream NF-kappaB expression in sinus tissues of patients with CRS.METHODS: A total of 31 CRS patients and 11 control patients with other diseases undergoing endoscopic sinus surgery were recruited consecutively. Theirrandom sinonasal tissue specimens were examined for the formation of biofilms by scanning electron microscopy. The relative levels of TLR2, TLR4, andNF-kappaB expression in those sinus tissues were determined by quantitative real-time reverse-transcriptase polymerase chain reaction and immunohistochemistry.RESULTS: Bacterial biofilms were detected in 20 of 31 samples from CRS patients but not in a single sample from control patients. The relative levels of TLR2, TLR4, and NF-kappaB expression in sinus tissues from CRS patients were significantly higher than that of controls, and the relative levels of TLR2 and NF-kappaB, but not TLR4, in biofilm-positive sinus tissues were significantly higher than that in biofilm-negative tissues of those CRS patients.CONCLUSION: Our data indicated that bacterial biofilms were associated with higher levels of TLR2 and NF-kappaB in the majority of sinus tissues frompatients with CRS. |
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Authors:
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Y Sun; B Zhou; C Wang; Q Huang; Q Zhang; Y Han; W Dai; E Fan; Y Li |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-16 |
Journal Detail:
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Title: American journal of rhinology & allergy Volume: - ISSN: 1945-8932 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101490775 Medline TA: Am J Rhinol Allergy Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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