Document Detail

Bioengineering functional copolymers. XXI. Synthesis of a novel end carboxyl-trithiocarbonate functionalized poly(maleic anhydride) and its interaction with cancer cells.
MedLine Citation:
PMID:  22796348     Owner:  NLM     Status:  Publisher    
A novel carboxyl-trithiocarbonate functionalized polymer with a highly selective antitumor activity was synthesized by a reversible addition-fragmentation chain transfer (RAFT) polymerization of maleic anhydride (MA) with benzoyl peroxide as an initiator and S-1-dodecyl-S-(α,α'-dimethyl-α″-acetic acid)trithiocarbonate as a RAFT agent with the aim to design and synthesize an effective anticancer agent with minimum side effects. The structure, molecular weights and composition of synthesized polymers were investigated by (1)H ((13)C) NMR, MALDI-TOF-MS and GPC analyzes. It was demonstrated that RAFT polymerization of MA was accompanied by a partially controlled decarboxylation of anhydride units and the formation of conjugated double bond fragments in backbone macromolecular chains. The mechanism of interaction of pristine RAFT agent and PMA-RAFT polymer with cancer (HeLa human cervix carcinoma) and normal (L929 Fibroblast) cells was investigated by using a combination of chemical, biochemical, statistical, spectroscopic (SEM and fluorescence inverted microscope) and real-time analysis (RTCA) methods. PMA-RAFT exhibited higher and selective cytotoxicity, apoptotic and necrotic effects toward HeLa cells at relatively low concentrations (around 7.5-75μgmL(-1), IC(50)=11.183μgmL(-1)) and toward Fibroblast cells at high concentrations (IC(50)>100μgmL(-1)). The observed highly selective antitumor activity render PMA-RAFT polymers as promising candidates for the utilization in cancer chemotherapy.
Zakir M O Rzayev; Mustafa Tűrk; Ernur A Söylemez
Related Documents :
3608078 - Inhibition of radiation-induced transformation of c3h/10t1/2 cells by chymotrypsin inhi...
22304908 - Immune cells exploit a neural circuit to enter the cns.
410028 - Induction of spectrin in erythroleukemic cells transformed by friend virus.
8137318 - Is there a significant role for lipid peroxidation in the causation of malignancy and f...
1533518 - Increase of neutral endopeptidase-24.11 with cellular density and enzyme modulation wit...
25038248 - Proceedings: international regulatory considerations on development pathways for cell t...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-5
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  -     ISSN:  1464-3391     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-7-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Institute of Science & Engineering, Division of Nanotechnology and Nanomedicine, Hacettepe University, Beytepe 06800, Ankara, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ambulatory arterial stiffness indices and non-alcoholic fatty liver disease in essential hypertensio...
Next Document:  Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as pot...