Document Detail


Bioengineering of articular cartilage: past, present and future.
MedLine Citation:
PMID:  23627827     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The treatment of cartilage defects poses a clinical challenge owing to the lack of intrinsic regenerative capacity of cartilage. The use of tissue engineering techniques to bioengineer articular cartilage is promising and may hold the key to the successful regeneration of cartilage tissue. Natural and synthetic biomaterials have been used to recreate the microarchitecture of articular cartilage through multilayered biomimetic scaffolds. Acellular scaffolds preserve the microarchitecture of articular cartilage through a process of decellularization of biological tissue. Although promising, this technique often results in poor biomechanical strength of the graft. However, biomechanical strength could be improved if biomaterials could be incorporated back into the decellularized tissue to overcome this limitation.
Authors:
Ken Ye; Raed Felimban; Simon E Moulton; Gordon G Wallace; Claudia Di Bella; Kathy Traianedes; Peter Fm Choong; Damian E Myers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Regenerative medicine     Volume:  8     ISSN:  1746-076X     ISO Abbreviation:  Regen Med     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278116     Medline TA:  Regen Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  333-49     Citation Subset:  IM    
Affiliation:
Department of Surgery, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria 3065, Australia.
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