Document Detail

Bioengineered probiotics, a strategic approach to control enteric infections.
MedLine Citation:
PMID:  23327986     Owner:  NLM     Status:  MEDLINE    
Enteric infections account for high morbidity and mortality and are considered to be the fifth leading cause of death at all ages worldwide. Seventy percent of all enteric infections are foodborne. Thus significant efforts have been directed toward the detection, control and prevention of foodborne diseases. Many antimicrobials including antibiotics have been used for their control and prevention. However, probiotics offer a potential alternative intervention strategy owing to their general health beneficial properties and inhibitory effects against foodborne pathogens. Often, antimicrobial probiotic action is non-specific and non-discriminatory or may be ineffective. In such cases, bioengineered probiotics expressing foreign gene products to achieve specific function is highly desirable. In this review we summarize the strategic development of recombinant bioengineered probiotics to control enteric infections, and to examine how scientific advancements in the human microbiome and their immunomodulatory effects help develop such novel and safe bioengineered probiotics.
Mary Anne Roshni Amalaradjou; Arun K Bhunia
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-17
Journal Detail:
Title:  Bioengineered     Volume:  4     ISSN:  2165-5987     ISO Abbreviation:  Bioengineered     Publication Date:    2013 Nov-Dec
Date Detail:
Created Date:  2013-12-16     Completed Date:  2014-08-06     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  101581063     Medline TA:  Bioengineered     Country:  United States    
Other Details:
Languages:  eng     Pagination:  379-87     Citation Subset:  IM    
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MeSH Terms
Anti-Infective Agents / administration & dosage,  pharmacology*
Food Technology / methods*
Foodborne Diseases / prevention & control*
Models, Animal
Probiotics / administration & dosage,  pharmacology*
Stress, Physiological
Reg. No./Substance:
0/Anti-Infective Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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