Document Detail


Bioengineered probes for molecular magnetic resonance imaging in the nervous system.
MedLine Citation:
PMID:  22896803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of molecular imaging probes has changed the nature of neurobiological research. Some of the most notable successes have involved the use of biological engineering techniques for the creation of fluorescent protein derivatives for optical imaging, but recent work has also led to a number of bioengineered probes for magnetic resonance imaging (MRI), the preeminent technique for noninvasive investigation of brain structure and function. Molecular MRI agents are beginning to be applied for experiments in the nervous system, where they have the potential to bridge from molecular to systems or organismic levels of analysis. Compared with canonical synthetic small molecule agents, biomolecular or semibiosynthetic MRI contrast agents offer special advantages due to their amenability to molecular engineering approaches, their properties in some cases as catalysts, and their specificity in targeting and ligand binding. Here, we discuss an expanding list of instances where biological engineering techniques have aided in the design of MRI contrast agents and reporter systems, examining both advantages and limitations of these types of probes for studies in the central nervous system.
Authors:
Vivian Hsieh; Alan Jasanoff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-07-11
Journal Detail:
Title:  ACS chemical neuroscience     Volume:  3     ISSN:  1948-7193     ISO Abbreviation:  ACS Chem Neurosci     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-16     Completed Date:  2013-04-10     Revised Date:  2013-08-18    
Medline Journal Info:
Nlm Unique ID:  101525337     Medline TA:  ACS Chem Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  593-602     Citation Subset:  IM    
Affiliation:
Departments of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 16-561, Cambridge, Massachusetts 02139, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bioengineering / methods*
Catalysis
Contrast Media
Humans
Magnetic Resonance Imaging / methods*
Molecular Imaging
Molecular Probes*
Nervous System Physiological Phenomena*
Neuroimaging / trends*
Neurosciences / methods*
Grant Support
ID/Acronym/Agency:
DP2-OD002114/OD/NIH HHS; R01 DA028299/DA/NIDA NIH HHS; R01-DA028299/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Molecular Probes
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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