Document Detail

Bioenergetics of different brain areas after experimental subarachnoid hemorrhage in rats.
MedLine Citation:
PMID:  3354025     Owner:  NLM     Status:  MEDLINE    
We studied energy metabolism after experimental subarachnoid hemorrhage in rats. Four different cerebral areas were tested: frontal cortex, occipital cortex, hippocampus, and brainstem. Vmax of the following enzymatic activities was evaluated: in the homogenate: hexokinase, phosphofructokinase, and lactate dehydrogenase for the glycolytic pathway, and glucose-6-phosphate dehydrogenase for the hexose monophosphate shunt; in the purified nonsynaptic mitochondria: NAD+-isocitrate dehydrogenase, citrate synthase, and succinate dehydrogenase for the Krebs cycle, and cytochrome oxidase for the electron transfer chain. We also evaluated some parameters related to the respiration of nonsynaptic mitochondria (State 3, State 4, uncoupled state, respiratory control ratio, and ADP:O ratio). Subarachnoid hemorrhage did not significantly affect Vmax of the enzymatic activities related to anaerobic and aerobic metabolism; however, mitochondrial respiration was affected, particularly in the presence of NADH-producing substrates (glutamate + malate).
F Marzatico; P Gaetani; R Rodriguez y Baena; V Silvani; P Paoletti; G Benzi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  19     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-05-02     Completed Date:  1988-05-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  378-84     Citation Subset:  IM    
Institute of Pharmacology, Faculty of Science, Pavia, Italy.
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MeSH Terms
Adenosine Diphosphate / metabolism
Brain / enzymology,  metabolism*
Energy Metabolism*
Hippocampus / physiopathology
Mitochondria / metabolism
Oxygen / metabolism
Rats, Inbred Strains
Subarachnoid Hemorrhage / enzymology,  metabolism*,  physiopathology
Reg. No./Substance:
58-64-0/Adenosine Diphosphate; 7782-44-7/Oxygen

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