| Bioenergetics of acute vasogenic edema. | |
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MedLine Citation:
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PMID: 7420167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The bioenergetic mechanisms of vasogenic edema were studied by measuring concentrations of adenosine triphosphate (ATP), phosphocreatine (CrP), and lactate in rapidly frozen edematous white matter in cats. When edema was produced using a cold lesion, it was found that both ATP and CrP were reduced to one-half of control values, and that lactate was elevated. When a correction was applied for dilution, however, it was found that high-energy phosphates were equal to control values, and that lactate was even more significantly elevated. This pattern contrasted with that seen in white-matter ischemia, in which CrP is depressed out of proportion to ATP. Finally, it was found that the white-matter lactate-concentration in the plasma infusion model of edema was increased. It is concluded that vasogenic edema induces an increase in lactate, but does not deplete high-energy phosphate compounds in affected white matter. |
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Authors:
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L N Sutton; F Welsh; D A Bruce |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurosurgery Volume: 53 ISSN: 0022-3085 ISO Abbreviation: J. Neurosurg. Publication Date: 1980 Oct |
Date Detail:
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Created Date: 1980-12-16 Completed Date: 1980-12-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 470-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Brain / metabolism Brain Edema / etiology, metabolism* Brain Ischemia / metabolism Cats Cold Temperature Energy Metabolism* Lactates / metabolism Male Phosphocreatine / metabolism Vasomotor System / physiology |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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