Document Detail

Bioenergetic abnormalities associated with severe left ventricular hypertrophy.
MedLine Citation:
PMID:  8349829     Owner:  NLM     Status:  MEDLINE    
Transmurally localized 31P-nuclear magnetic resonance spectroscopy (NMR) was used to study the effect of severe pressure overload left ventricular hypertrophy (LVH) on myocardial high energy phosphate content. Studies were performed on 8 normal dogs and 12 dogs with severe left ventricular hypertrophy produced by banding the ascending aorta at 8 wk of age. Spatially localized 31P-NMR spectroscopy provided measurements of the transmural distribution of myocardial ATP, phosphocreatine (CP), and inorganic phosphate (Pi); spectra were calibrated from measurements of ATP content in myocardial biopsies using HPLC. Blood flow was measured with microspheres. In hypertrophied hearts during basal conditions, ATP was decreased by 42%, CP by 58%, and the CP/ATP ratio by 32% in comparison with normal. Increasing myocardial blood flow with adenosine did not correct these abnormalities, indicating that they were not the result of persistent hypoperfusion. Atrial pacing at 200 and 240 beats per min caused no change in high energy phosphate content in normal hearts but resulted in further CP depletion with Pi accumulation in the inner left ventricular layers of the hypertrophied hearts. These changes were correlated with redistribution of blood flow away from the subendocardium in LVH hearts. These findings demonstrate that high energy phosphate levels and the CP/ATP ratio are significantly decreased in severe LVH. These abnormalities are proportional to the degree of hypertrophy but are not the result of persistent abnormalities of myocardial perfusion. In contrast, depletion of CP and accumulation of Pi during tachycardia in LVH are closely related to the pacing-induced perfusion abnormalities and likely reflect subendocardial ischemia.
J Zhang; H Merkle; K Hendrich; M Garwood; A H From; K Ugurbil; R J Bache
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  92     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-09-15     Completed Date:  1993-09-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  993-1003     Citation Subset:  AIM; IM    
Department of Medicine, University of Minnesota, Minneapolis.
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MeSH Terms
Adenosine / metabolism
Adenosine Triphosphate / metabolism
Blood Pressure
Body Weight
Creatinine / metabolism
Energy Metabolism*
Heart / physiology,  physiopathology*
Heart Rate
Hypertrophy, Left Ventricular / metabolism,  physiopathology*
Magnetic Resonance Spectroscopy / methods
Myocardium / metabolism*
Organ Size
Phosphates / metabolism
Phosphocreatine / metabolism
Reference Values
Grant Support
Reg. No./Substance:
0/Phosphates; 56-65-5/Adenosine Triphosphate; 58-61-7/Adenosine; 60-27-5/Creatinine; 67-07-2/Phosphocreatine; 7723-14-0/Phosphorus

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