| Bioencapsulation of the hepatitis B surface antigen and its use as an effective oral immunogen. | |
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MedLine Citation:
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PMID: 22406456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatitis B remains a major global health problem despite the availability of a safe and effective vaccine. Segments of the population lack access to or respond poorly to the parenteral vaccine, perpetuating the infection-transmission cycle. A low cost, orally delivered vaccine has the potential to alleviate many of these problems. Here we describe the expression of a bioencapsulated hepatitis B surface antigen (HBsAg) in maize and its immunogenicity, demonstrating for the first time a commercially feasible oral subunit vaccine production system for a major disease. This work surmounts previous barriers to plant-produced vaccines by expressing HBsAg at much higher levels and retaining antigen immunogenicity post-processing: factors which facilitated a robust immune response in mice without the need for an adjuvant. This method provides a practical solution to the delivery of a low-cost, stable oral vaccine. |
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Authors:
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Celine A Hayden; Stephen J Streatfield; Barry J Lamphear; Gina M Fake; Todd K Keener; John H Walker; John D Clements; Debra D Turner; Ian R Tizard; John A Howard |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-03-08 |
Journal Detail:
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Title: Vaccine Volume: 30 ISSN: 1873-2518 ISO Abbreviation: Vaccine Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-09 Completed Date: 2012-07-27 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 8406899 Medline TA: Vaccine Country: Netherlands |
Other Details:
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Languages: eng Pagination: 2937-42 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Applied Biotechnology Institute, Cal Poly Tech Park, San Luis Obispo, CA 93407, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Antibodies, Viral / blood Drug Delivery Systems* Hepatitis B Surface Antigens / administration & dosage*, immunology* Hepatitis B Vaccines / administration & dosage*, immunology* Mice Mice, Inbred BALB C Vaccines, Edible / administration & dosage, immunology Zea mays / genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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1R43AI068239-01A1/AI/NIAID NIH HHS; 3R43AI068239-01A1S1/AI/NIAID NIH HHS; R43 AI068239-01A1/AI/NIAID NIH HHS; R43 AI068239-01A1S1/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/Hepatitis B Surface Antigens; 0/Hepatitis B Vaccines; 0/Vaccines, Edible |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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