| Bioelectric mechanisms in regeneration: Unique aspects and future perspectives. | |
| | |
MedLine Citation:
|
PMID: 19406249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Regenerative biology has focused largely on chemical factors and transcriptional networks. However, endogenous ion flows serve as key epigenetic regulators of cell behavior. Bioelectric signaling involves feedback loops, long-range communication, polarity, and information transfer over multiple size scales. Understanding the roles of endogenous voltage gradients, ion flows, and electric fields will contribute to the basic understanding of numerous morphogenetic processes and the means by which they can robustly restore pattern after perturbation. By learning to modulate the bioelectrical signals that control cell proliferation, migration, and differentiation, we gain a powerful set of new techniques with which to manipulate growth and patterning in biomedical contexts. This chapter reviews the unique properties of bioelectric signaling, surveys molecular strategies and reagents for its investigation, and discusses the opportunities made available for regenerative medicine. |
| | |
Authors:
|
Michael Levin |
Related Documents
:
|
22861119 - Fluorinated pcpdtbt with enhanced open circuit voltage and reduced recombination for hi... 18159939 - Operating regimes of signaling cycles: statics, dynamics, and noise filtering. 20372449 - Time-coded aperture design for nuclear medicine imaging: a study of signal-to-noise ratio. 19847019 - Device variability and circuit redundancy in signal processing based on nanoswitches. 18002909 - Ensemble spontaneous activity alterations detected by cisa approach. 21672669 - Numerical model of heat transfer in the rabbit eye exposed to 60-ghz millimeter wave ra... 19895139 - New method of estimating wavelength-dependent optical path length ratios for oxy- and d... 16220689 - Dna microarray stochastic model. 12144099 - A statistical model for the heterogeneous structure of porous catalyst pellets. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-05-03 |
Journal Detail:
|
Title: Seminars in cell & developmental biology Volume: 20 ISSN: 1096-3634 ISO Abbreviation: Semin. Cell Dev. Biol. Publication Date: 2009 Jul |
Date Detail:
|
Created Date: 2009-07-06 Completed Date: 2009-09-10 Revised Date: 2011-03-21 |
Medline Journal Info:
|
Nlm Unique ID: 9607332 Medline TA: Semin Cell Dev Biol Country: England |
Other Details:
|
Languages: eng Pagination: 543-56 Citation Subset: IM |
Affiliation:
|
Tufts Center for Regenerative and Developmental Biology, Biology Department, Tufts University, Medford, MA 02155, USA. michael.levin@tufts.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bioelectric Energy Sources* Membrane Potentials / physiology Morphogenesis Regeneration / physiology* Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
|
GM078484/GM/NIGMS NIH HHS; HD055850/HD/NICHD NIH HHS; P41 RR001395/RR/NCRR NIH HHS; R01 EY018168-01A1/EY/NEI NIH HHS; R01 GM077425-03/GM/NIGMS NIH HHS; R01 GM078484-02/GM/NIGMS NIH HHS; R21 HD055850-02/HD/NICHD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Autophagy and plant innate immunity: Defense through degradation.
Next Document: Nutrient profiling reveals potent inducers of trichothecene biosynthesis in Fusarium graminearum.