Document Detail

Bioeffects of positive and negative acoustic pressures in mice infused with microbubbles.
MedLine Citation:
PMID:  11120371     Owner:  NLM     Status:  MEDLINE    
This study provided one test of the hypothesis that hemorrhage in tissues containing ultrasound (US) contrast agents results from inertial cavitation. The test relied on the prediction of classical cavitation theory that the response of microbubbles to negative pressures is much greater than it is for positive pressures. An endoscopic electrohydraulic lithotripter was used to generate a spherically diverging positive pressure pulse. A negative pressure pulse was produced by reflection of the positive pulse from a pressure release interface. Mice were injected with approximately 0. 1 mL of Albunex(R) and exposed to 100 pulses at either + 3.6 MPa or -3.6 MPa pressure amplitude. For comparison, mice were also exposed to the same acoustic fields without injection of contrast agents. Sham animals experienced the same protocols, with or without Albunex(R) injections, but were not exposed to the lithotripter fields. Following exposure, mice were scored for hemorrhage to various organs and tissues. When Albunex(R) was present in the vasculature, negative pressure pulses produced significantly more hemorrhage than positive pressures in tissues such as the kidney, intestine, skin, muscle, fat, mesentery and stomach.
D Dalecki; S Z Child; C H Raeman; C Xing; S Gracewski; E L Carstensen
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  26     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-01-22     Completed Date:  2001-02-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1327-32     Citation Subset:  IM    
Departments of Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY, USA.
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MeSH Terms
Albumins / administration & dosage,  adverse effects*
Contrast Media / administration & dosage,  adverse effects*
Gastrointestinal Hemorrhage / etiology
Hemorrhage / etiology
Injections, Intravenous
Lithotripsy / adverse effects
Mice, Inbred Strains
Ultrasonography / adverse effects*
Grant Support
Reg. No./Substance:
0/Albumins; 0/Albunex; 0/Contrast Media

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