| Biodistributions of 201Tl in tumor bearing animals and inflammatory lesion induced animals. | |
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MedLine Citation:
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PMID: 2952508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The accumulation of 201Tl in tumor and inflammatory tissues were small. However, this nuclide showed a high concentration in viable tumor tissue, less in connective tissue (containing inflammatory tissue), and was not seen in necrotic tumor tissue regardless of the time after administration of 201Tl(I)-chloride. In inflammatory lesions, 201Tl accumulated in subcutaneous tissue infiltrated with neutrophils and macrophages, and quite large amounts of this nuclide were accumulated in subcutaneous tissue and sites where neutrophils were crowded. Most 201Tl existed in a free form in the fluid of tumor and inflammatory tissues regardless of the time after administration. A small amount of this nuclide was localized in the nuclear, mitochondrial and microsomal fractions in these tissues, and the nuclide was bound to protein in these fractions. The distribution of 201Tl(III)-chloride in tumor bearing animals was essentially the same as that of 201Tl(I)-chloride. |
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Authors:
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A Ando; I Ando; M Katayama; S Sanada; T Hiraki; H Mori; N Tonami; K Hisada |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of nuclear medicine Volume: 12 ISSN: 0340-6997 ISO Abbreviation: Eur J Nucl Med Publication Date: 1987 |
Date Detail:
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Created Date: 1987-06-09 Completed Date: 1987-06-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7606882 Medline TA: Eur J Nucl Med Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 567-72 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, Gel Gallium Radioisotopes / metabolism Glycosaminoglycans / metabolism Inflammation / metabolism* Male Microsomes / metabolism Mitochondria / metabolism Neoplasms, Experimental / metabolism* Radioisotopes / metabolism* Rats Thallium / metabolism* Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Gallium Radioisotopes; 0/Glycosaminoglycans; 0/Radioisotopes; 7440-28-0/Thallium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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