| Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-L-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT. | |
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MedLine Citation:
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PMID: 20056428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new phenylboric acid derivative entrapped lipiodol (PBAD-lipiodol) was developed as a boron carrier for the boron neutron capture therapy (BNCT) of hepatoma in Taiwan. The biodistribution of both PBAD-lipiodol and BPA-fructose was assayed in GP7TB hepatoma-bearing rat model. The highest uptake of PBAD-lipiodol was found at 2h post injection. The application of BNCT for the hepatoma treatment in tumor-bearing rats is suggested to be 2-4h post PBAD-lipiodol injection. |
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Authors:
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A H Liao; F I Chou; Y C Kuo; H W Chen; J J Kai; C W Chang; F D Chen; J J Hwang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-23 |
Journal Detail:
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Title: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine Volume: 68 ISSN: 1872-9800 ISO Abbreviation: Appl Radiat Isot Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306253 Medline TA: Appl Radiat Isot Country: England |
Other Details:
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Languages: eng Pagination: 422-6 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Boron Neutron Capture Therapy / methods* Boronic Acids / chemical synthesis, pharmacokinetics*, pharmacology Fluorine Radioisotopes / pharmacokinetics*, pharmacology Iodized Oil / chemical synthesis, pharmacokinetics*, pharmacology Liver Neoplasms, Experimental / metabolism*, radiotherapy Magnetic Resonance Imaging Male Phenylalanine / analogs & derivatives*, chemical synthesis, pharmacokinetics, physiology Rats Rats, Inbred F344 Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Boronic Acids; 0/Fluorine Radioisotopes; 63-91-2/Phenylalanine; 8001-40-9/Iodized Oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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