| Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 19581716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe(3)O(4)) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized. |
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Authors:
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Shigeaki Abe; Ikuhiro Kida; Mitsue Esaki; Tsukasa Akasaka; Motohiro Uo; Toshiaki Hosono; Yoshinori Sato; Balachandran Jeyadevan; Yoshinori Kuboki; Manabu Morita; Kazuyuki Tohji; Fumio Watari |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bio-medical materials and engineering Volume: 19 ISSN: 0959-2989 ISO Abbreviation: Biomed Mater Eng Publication Date: 2009 |
Date Detail:
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Created Date: 2009-07-07 Completed Date: 2009-08-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9104021 Medline TA: Biomed Mater Eng Country: Netherlands |
Other Details:
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Languages: eng Pagination: 213-20 Citation Subset: IM |
Affiliation:
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Department of Biomedical Materials and Engineering, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan. sabe@den.hokudai.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Media / chemistry*, pharmacokinetics* Ferrosoferric Oxide / chemistry*, diagnostic use, pharmacokinetics* Magnetic Resonance Imaging / methods* Male Mice Mice, Inbred ICR Microscopy, Fluorescence / methods Organ Specificity Tissue Distribution Whole Body Imaging / methods* X-Rays |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 1317-61-9/Ferrosoferric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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