Document Detail


Biodistribution of human MHC non-restricted TALL-104 killer cells in healthy and tumor bearing mice.
MedLine Citation:
PMID:  9917498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human cytotoxic T cell line TALL-104 displays potent anti-tumor effects in animals with spontaneous and induced malignancies. We investigated the biodistribution of TALL-104 cells in tumor bearing and healthy mice. 111In-labeled TALL-104 cells, injected intravenously, localized primarily in the lungs for the first 2 h, and redistributed to liver, spleen, and kidneys in the following 24 h both in immunodeficient and immunocompetent mice. TALL-104 cells consistently accumulated in the tumor and at sites of metastases. In animals injected with free 111In-oxine, most of the radioactivity remained in the blood pool with no significant organ accumulation. These data support the tumor homing properties of TALL-104 cells, information which is crucial to their therapeutic efficacy in forthcoming clinical trials.
Authors:
A Cesano; S Visonneau; T Tran; D Santoli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of oncology     Volume:  14     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-02-16     Completed Date:  1999-02-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  245-51     Citation Subset:  IM    
Affiliation:
The Wistar Institute, Philadelphia, PA 19104, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Cell Movement / immunology
Humans
Immunotherapy, Adoptive*
Indium Radioisotopes
Killer Cells, Natural / immunology*,  pathology,  transplantation
Major Histocompatibility Complex / immunology*
Mice
Neoplasms, Experimental / immunology*,  pathology,  therapy
Transplantation, Heterologous
Grant Support
ID/Acronym/Agency:
CA-10815/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Indium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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