Document Detail


Biodistribution of dual radiolabeled lipidic nanocapsules in the rat using scintigraphy and gamma counting.
MedLine Citation:
PMID:  12176281     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present work was to study the biodistribution of a radiolabeled lipidic nanocapsule formulation after intravenous administration in rat by scintigraphy and gamma counting. This formulation is expected to be used as anticancer agent delivery devices and as transfection complexes. For this purpose, 99mTc-oxine was incorporated in the lipidic core, while 125I labeled tensioactive shell of the nanocapsule. First, in vitro stability of radiolabeled nanocapsules was evaluated by dialysis against distilled water and size measurements. Second, the nanocapsule biodistribution was followed after intravenous administration for 3 h by dynamic scintigraphic acquisition and up to 24 h by determining the gamma activity in blood and tissues. Radiolabeling was efficient and stable in vitro. After intravenous injection blood radioactivity decreased with an early half disappearance time of about 45 min for both radioisotopes. Liver and intestine radioactivities raised up to 24 h. The relatively long remanence in blood of the tracers which is probably due to the presence of PEG at the nanocarrier surface seems promising for the use of these solvent free lipidic nanocapsules as carrier of lipophilic drugs.
Authors:
A Cahouet; B Denizot; F Hindré; C Passirani; B Heurtault; M Moreau; J Le Jeune; J Benoît
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  242     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-14     Completed Date:  2002-10-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  367-71     Citation Subset:  IM    
Affiliation:
Inserm ERIT-M 0104,'Ingénierie de la Vectorisation Particulaire', 10 rue A. Bocquel, 49100, Angers, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Capsules
Drug Carriers
Half-Life
Injections, Intravenous
Iodine Radioisotopes / administration & dosage
Lipids
Oxyquinoline / administration & dosage,  pharmacokinetics
Phosphatidylethanolamines / chemistry
Radiopharmaceuticals / administration & dosage*,  pharmacokinetics*
Rats
Sodium Pertechnetate Tc 99m / administration & dosage,  pharmacokinetics
Tissue Distribution
Chemical
Reg. No./Substance:
0/Capsules; 0/Drug Carriers; 0/Iodine Radioisotopes; 0/Lipids; 0/Phosphatidylethanolamines; 0/Radiopharmaceuticals; 148-24-3/Oxyquinoline; 23288-60-0/Sodium Pertechnetate Tc 99m

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