| Biodistribution of canine leucocytes labelled with technetium-99m stannous fluoride colloid in whole blood and their ability to localise to sites of induced inflammation. | |
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MedLine Citation:
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PMID: 19560377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study assessed the biodistribution of autologous leucocytes radiolabelled with technetium-99m stannous fluoride colloid (99mTcSnC) for detection of foci of induced inflammation in dogs. Venous blood was collected from seven healthy dogs and incubated with 99mTcSnC for 1h at room temperature. Radiolabelled samples were injected intravenously (IV) and the dogs were scanned using a gamma camera. Another seven healthy dogs were injected intradermally with tumour necrosis factor alpha and then IV with 99mTcSnC radiolabelled autologous blood 3h later before being scanned. The radiolabelled leucocytes localised to sites of inflammation by 30 min post-injection. IV injection of autologous leucocytes radiolabelled with 99mTcSnC appears to be a sensitive method for localisation of induced foci of inflammation in dogs. |
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Authors:
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Mohamed H Abushhiwa; Nouria S Salehi; Meir Lichtenstein; Peter M Lording; Peter J Finnin; Robert C Whitton; Jennifer A Charles; Bruce W Parry |
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Publication Detail:
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Type: Journal Article Date: 2009-06-26 |
Journal Detail:
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Title: Veterinary journal (London, England : 1997) Volume: 185 ISSN: 1532-2971 ISO Abbreviation: Vet. J. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-10-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706281 Medline TA: Vet J Country: England |
Other Details:
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Languages: eng Pagination: 157-62 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Faculty of Veterinary Science, The University of Melbourne, Werribee, Victoria 3030, Australia. m.abushhiwa@pgrad.unimelb.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dog Diseases / diagnosis, metabolism*, radionuclide imaging* Dogs Female Inflammation / diagnosis, metabolism, radionuclide imaging, veterinary* Injections, Intravenous / veterinary Leukocytes / chemistry, metabolism* Male Technetium Compounds / diagnostic use Tissue Distribution Tumor Necrosis Factor-alpha / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Technetium Compounds; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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