Document Detail


Biodistribution of anti-CEA F(ab')2 fragments after intra-arterial and intravenous injection in patients with liver metastases due to colorectal carcinoma.
MedLine Citation:
PMID:  8822748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The biodistribution of simultaneous intra-arterial and intravenous injections of a radiolabelled anti-CEA MAb F(ab')2 fragment was studied in three patients with liver metastases from colorectal cancer. Identical MAb fragments, labelled with either 125I or 131I, were injected over a period of 30 min into the hepatic artery and into a peripheral vein. After 1 or 2 days, biodistribution was measured in the surgically removed metastases, normal tissue samples and blood. By tissue radioactivity counting, tumour uptake in the range 6.3-9.1% of injected dose per gram was found. Superimposable metastasis-to-blood and metastasis-to-normal liver ratios were obtained for both iodine isotopes in all three patients. The results indicate that the intra-arterial injection of MAb F(ab')2 fragments gives no measurable advantage over more convenient injections into a peripheral vein.
Authors:
F Buchegger; M Gillet; F Doenz; C A Vogel; C Achtari; J P Mach; B Delaloye; A B Delaloye
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  17     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1997-02-07     Completed Date:  1997-02-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  500-3     Citation Subset:  IM    
Affiliation:
DIvision of Nuclear Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal
Carcinoembryonic Antigen / immunology
Colonic Neoplasms / pathology,  radionuclide imaging*
Female
Humans
Immunoglobulin Fab Fragments
Injections, Intra-Arterial
Injections, Intravenous
Iodine Radioisotopes / administration & dosage,  diagnostic use,  pharmacokinetics
Liver Neoplasms / pathology,  radionuclide imaging*,  secondary*,  surgery
Male
Middle Aged
Radioimmunodetection*
Rectal Neoplasms / pathology,  radionuclide imaging*
Sensitivity and Specificity
Tissue Distribution
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Carcinoembryonic Antigen; 0/Immunoglobulin Fab Fragments; 0/Iodine Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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