Document Detail

Biodegradation of malachite green and rhodamine B by caecal microflora of rats.
MedLine Citation:
PMID:  8185609     Owner:  NLM     Status:  MEDLINE    
Bio-degradation of two non-permitted dyes namely Malachite green and Rhodamine B, commonly encountered in the food commodities, through rat caecal microflora was studied. Malachite green was biotransformed by caecal microflora to one fluorescent metabolite with a Rf value of 0.09. Incubation of Rhodamine B with caecal microflora resulted in two fluorescent metabolites with Rf values of 0.72 and 0.09. The DI50 value of Malachite green was quite low (10 min), while that of Rhodamine B could not be derived as the maximum degradation was only 32%. The results suggest that Malachite green and Rhodamine B are biotransformed to different metabolites by rat caecal microflora which may help in delineating the mechanism of carcinogenic potential of these two dyes.
S Singh; M Das; S K Khanna
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  200     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-06-16     Completed Date:  1994-06-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1544-50     Citation Subset:  IM    
Dyes & Food Adulterant Toxicology Laboratory Industrial Toxicology Research Centre, Lucknow, India.
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MeSH Terms
Cecum / metabolism*,  microbiology
Fluorescent Dyes
Rats, Wistar
Rhodamines / metabolism*
Rosaniline Dyes / metabolism*
Reg. No./Substance:
0/Fluorescent Dyes; 0/Rhodamines; 0/Rosaniline Dyes; 10309-95-2/malachite green; 14899-08-2/rhodamine B

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