Document Detail

Biodegradation of alpha-hexachlorocyclohexane. VI. The cechlorination of alpha-hexachlorocyclohexane by microsomes and cytosol of rat liver.
MedLine Citation:
PMID:  53794     Owner:  NLM     Status:  MEDLINE    
Alpha-hexachlorocyclohexane (alpha-HCH) is dechlorinated by enzymes contained in rat liver cytosol and microsomes. An evidence was obtained that in the cytosol there are two alpha-HCH dechlorinating enzymes at least; one operates only in the presence of reduced glutathione (GSH) and catalyzes dechlorinations associated with the formation of another hydrophilic product. This product is probably a conjugate of the alpha-HCH-residue with GSH. The other cytoplasmic alpha-HCH-dechlorinase requires no additions. The microsomes, too, contain two alpha-HC dechlorinases at least: one is stimulated by GSH, the other by NADPH.
P Kraus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  291     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1975  
Date Detail:
Created Date:  1976-02-19     Completed Date:  1976-02-19     Revised Date:  2010-03-12    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  79-87     Citation Subset:  IM    
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MeSH Terms
Biodegradation, Environmental
Carbon Monoxide / pharmacology
Cytosol / metabolism*
Glutathione / pharmacology
Lindane / metabolism*
Liver / metabolism*,  ultrastructure
Microsomes, Liver / metabolism*
NADP / pharmacology
Proadifen / pharmacology
Sulfobromophthalein / pharmacology
Reg. No./Substance:
297-83-6/Sulfobromophthalein; 302-33-0/Proadifen; 53-59-8/NADP; 58-89-9/Lindane; 630-08-0/Carbon Monoxide; 67-64-1/Acetone; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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