| Biodegradable xylitol-based elastomers: in vivo behavior and biocompatibility. | |
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MedLine Citation:
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PMID: 20540093 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biodegradable elastomers based on polycondensation reactions of xylitol with sebacic acid, referred to as poly(xylitol sebacate) (PXS) elastomers have recently been developed. We describe the in vivo behavior of PXS elastomers. Four PXS elastomers were synthesized, characterized, and compared with poly(L-lactic-co-glycolic acid) (PLGA). PXS elastomers displayed a high level of structural integrity and form stability during degradation. The in vivo half-life ranged from approximately 3 to 52 weeks. PXS elastomers exhibited increased biocompatibility compared with PLGA implants. |
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Authors:
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Joost P Bruggeman; Christopher J Bettinger; Robert Langer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical materials research. Part A Volume: 95 ISSN: 1552-4965 ISO Abbreviation: J Biomed Mater Res A Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-26 Completed Date: 2010-12-08 Revised Date: 2011-10-03 |
Medline Journal Info:
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Nlm Unique ID: 101234237 Medline TA: J Biomed Mater Res A Country: United States |
Other Details:
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Languages: eng Pagination: 92-104 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010. |
Affiliation:
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Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD / metabolism Antigens, Differentiation, Myelomonocytic / metabolism Biocompatible Materials / pharmacology* Elastomers / chemical synthesis, chemistry, pharmacology* Female Foreign-Body Reaction / pathology Implants, Experimental Lactic Acid / pharmacology Macrophage Activation / drug effects Materials Testing* Microscopy, Electron, Scanning Polyglycolic Acid / pharmacology Polymers / chemical synthesis, chemistry, pharmacology Rats Rats, Inbred Lew Subcutaneous Tissue / drug effects Time Factors Xylitol / chemical synthesis, chemistry, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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HL060435/HL/NHLBI NIH HHS; R01 HL060435-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/Biocompatible Materials; 0/CD68 antigen, human; 0/Elastomers; 0/Polymers; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid; 87-99-0/Xylitol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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