Document Detail


Biodegradable xylitol-based elastomers: in vivo behavior and biocompatibility.
MedLine Citation:
PMID:  20540093     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Biodegradable elastomers based on polycondensation reactions of xylitol with sebacic acid, referred to as poly(xylitol sebacate) (PXS) elastomers have recently been developed. We describe the in vivo behavior of PXS elastomers. Four PXS elastomers were synthesized, characterized, and compared with poly(L-lactic-co-glycolic acid) (PLGA). PXS elastomers displayed a high level of structural integrity and form stability during degradation. The in vivo half-life ranged from approximately 3 to 52 weeks. PXS elastomers exhibited increased biocompatibility compared with PLGA implants.
Authors:
Joost P Bruggeman; Christopher J Bettinger; Robert Langer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research. Part A     Volume:  95     ISSN:  1552-4965     ISO Abbreviation:  J Biomed Mater Res A     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-26     Completed Date:  2010-12-08     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  101234237     Medline TA:  J Biomed Mater Res A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  92-104     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD / metabolism
Antigens, Differentiation, Myelomonocytic / metabolism
Biocompatible Materials / pharmacology*
Elastomers / chemical synthesis,  chemistry,  pharmacology*
Female
Foreign-Body Reaction / pathology
Implants, Experimental
Lactic Acid / pharmacology
Macrophage Activation / drug effects
Materials Testing*
Microscopy, Electron, Scanning
Polyglycolic Acid / pharmacology
Polymers / chemical synthesis,  chemistry,  pharmacology
Rats
Rats, Inbred Lew
Subcutaneous Tissue / drug effects
Time Factors
Xylitol / chemical synthesis,  chemistry,  pharmacology*
Grant Support
ID/Acronym/Agency:
HL060435/HL/NHLBI NIH HHS; R01 HL060435/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/Biocompatible Materials; 0/CD68 antigen, human; 0/Elastomers; 0/Polymers; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 33X04XA5AT/Lactic Acid; VCQ006KQ1E/Xylitol
Comments/Corrections

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