Document Detail

Biodegradable versus durable polymer drug eluting stents in coronary artery disease: Insights from a meta-analysis of 5834 patients.
MedLine Citation:
PMID:  23152364     Owner:  NLM     Status:  Publisher    
Background: Biodegradable polymer drug eluting stents (BP-DES) have been developed to overcome the limitations of first generation durable polymer DES (DP-DES) but the clinical results of different BP-DES are not consistent. We performed a meta-analysis to compare the outcomes of BP-DES and DP-DES in the treatment of coronary artery disease (CAD).Methods and results: Online databases including MEDLINE were searched for studies comparing BP-DES and DP-DES for obstructive CAD that reported rates for overall mortality, myocardial infarction (MI), late stent thrombosis (LST), target lesion revascularization (TLR) and late lumen loss (LLL) with a follow-up of ≥6 months. Ten studies (5834 patients) with a 1-year median follow-up were included in the meta-analysis. When comparing patients treated with DP-DES and BP-DES those treated with BP-DES had lower LLL (in-stent: weighted mean difference (WMD) -0.10 mm, 95% CI = -0.17 to -0.03 mm, p = 0.004; in-segment: WMD -0.06 mm, 95% CI = -0.10 to -0.01 mm, p = 0.01) with lower TLR rates (OR 0.67, 95% CI = 0.47 to 0.98, p = 0.04). However, BP-DES did not improve mortality (OR 0.97, 95% CI = 0.73 to 1.29, p = 0.83), MI (OR 1.13, 95% CI = 0.87 to 1.46, p = 0.36) or LST rates (OR 0.64, 95% CI = 0.36 to 1.16, p = 0.14). A pre-specified subgroup analysis of Biolimus BP-DES confirmed significant LLL reduction without differences in other clinical endpoints. Meta-regression analysis demonstrated a strong significant inverse correlation between LLL and reference coronary diameter (p < 0.001).Conclusions: Our present meta-analysis showed that BP-DES when compared with DP-DES significantly reduced LLL and TVR but without clear benefits on mortality, MI and LST rates. ( identifier: NCT01466634).
Alessandro Lupi; Andrea Rognoni; Gioel Gabrio Secco; Maurizio Lazzero; Federico Nardi; Rossella Fattori; Angelo Sante Bongo; Pierfrancesco Agostoni; Imad Sheiban
Related Documents :
2440294 - Animal pharmacology of nicardipine and its clinical relevance.
9482144 - Myocardial ischemia in generalized coronary artery-left ventricular microfistulae.
24113324 - Direct comparison of adjacent endocardial and epicardial electrograms: implications for...
3751904 - Prognostic significance of asymptomatic coronary artery disease.
12470394 - Qt interval dynamics predict mortality in high-risk patients after myocardial infarction.
12890384 - Cardioprotective effects of morphine on rat heart suffering from ischemia and reperfusion.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  European journal of preventive cardiology     Volume:  -     ISSN:  2047-4881     ISO Abbreviation:  Eur J Prev Cardiol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101564430     Medline TA:  Eur J Prev Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Hospital Cardiology, ''Maggiore della Carità'' Hospital, Novara, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dehydroepiandrosterone sulfate levels and risk of atrial fibrillation: The Rotterdam Study.
Next Document:  Effects of Tat proteins and Tat mutants of different human immunodeficiency virus type 1 clades on g...