Document Detail


Biodegradable polymer networks based on oligolactide macromers: synthesis, properties and biomedical applications.
MedLine Citation:
PMID:  12202198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Novel linear and star-shaped oligolactide macromers were synthesized by ring-opening oligomerization of L-lactide in the presence of suitable initiators (di- and polyols, amino acid esters) and subsequent endgroup-functionalization of the formed oligolactides with methacrylate moities. The obtained liquid macromers are valuable building blocks for the preparation of biocompatible polymer networks. Based on these macromers, the fabrication and the material properties including biodegradation behaviour of highly porous polymer network devices will be described. The application of these materials as resorbable scaffolds in tissue engineering will be discussed.
Authors:
Matthias Schnabelrauch; Sebastian Vogt; Yves Larcher; Ingo Wilke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomolecular engineering     Volume:  19     ISSN:  1389-0344     ISO Abbreviation:  Biomol. Eng.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-30     Completed Date:  2003-03-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100928062     Medline TA:  Biomol Eng     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  295-8     Citation Subset:  IM    
Affiliation:
INNOVENT Technologieentwicklung e. V., Prüssingstr. 27B, 07745 Jena, Germany. ms@innovent-jena.de
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MeSH Terms
Descriptor/Qualifier:
Absorbable Implants*
Biocompatible Materials / chemistry
Bone Substitutes / chemistry*
Cell Line
Humans
Macromolecular Substances
Materials Testing / methods
Osteoblasts / metabolism*
Polyesters / chemistry*,  pharmacokinetics*
Polymers / chemistry
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Bone Substitutes; 0/Macromolecular Substances; 0/Polyesters; 0/Polymers; 26969-66-4/poly(lactide)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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