| Biodegradable amphiphilic triblock copolymer bearing pendant glucose residues: preparation and specific interaction with Concanavalin A molecules. | |
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MedLine Citation:
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PMID: 16768401 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel biodegradable amphiphilic block copolymer PLGG-PEG-PLGG bearing pendant glucose residues is successfully prepared by the coupling reaction of 3-(2-aminoethylthio)propyl-alpha-D-glucopyranoside with the pendant carboxyl groups of PLGG-PEG-PLGG in the presence of N,N'-carbonyldiimidazole. The polymer PLGG-PEG-PLGG, i.e., poly{(lactic acid)-co-[(glycolic acid)-alt-(L-glutamic acid)]}-block-poly(ethylene glycol)-block- poly{(lactic acid)-co-[(glycolic acid)-alt-(L-glutamic acid)]}, is prepared by ring-opening copolymerization of L-lactide (LLA) with (3s)-benzoxylcarbonylethylmorpholine-2,5-dione (BEMD) in the presence of dihydroxyl PEG with molecular weight of 2000 as macroinitiator and Sn(Oct)2 as catalyst, and then by catalytic hydrogenation. The glucose-grafted copolymer shows a lower degree of cytotoxicity to ECV-304 cells and improved specific recognition and binding with Concanavalin A (Con A). Therefore, this kind of glucose-grafted copolymer may find biomedical applications. |
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Authors:
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Changhai Lu; Xuesi Chen; Zhigang Xie; Tiancheng Lu; Xin Wang; Jia Ma; Xiabin Jing |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biomacromolecules Volume: 7 ISSN: 1525-7797 ISO Abbreviation: Biomacromolecules Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-13 Completed Date: 2006-11-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100892849 Medline TA: Biomacromolecules Country: United States |
Other Details:
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Languages: eng Pagination: 1806-10 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biodegradation, Environmental Cell Line Cell Survival / drug effects Concanavalin A / chemistry* Cysteamine / analogs & derivatives*, chemical synthesis, chemistry Endothelial Cells / drug effects Glucose / chemistry* Glucosides / chemical synthesis*, chemistry Humans Molecular Structure Polyesters / chemical synthesis*, chemistry, pharmacology Polyethylene Glycols / chemical synthesis*, chemistry, pharmacology Protein Binding |
| Chemical | |
Reg. No./Substance:
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0/3-(2-aminoethylthio)propyl glucopyranoside; 0/Glucosides; 0/Polyesters; 0/Polyethylene Glycols; 0/poly(lactic acid-co-((glycolic acid)-alt-(L-glutamic acid))glucose)-poly(ethylene glycol)-poly(lactic acid-co-((glycolic acid)-alt-(L-glutamic acid))glucose); 11028-71-0/Concanavalin A; 50-99-7/Glucose; 60-23-1/Cysteamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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