Document Detail

Bioconversion of progesterone by the activated immobilized conidia of Aspergillus ochraceus TS.
MedLine Citation:
PMID:  10525834     Owner:  NLM     Status:  MEDLINE    
Progesterone was transformed to its 11alpha-hydroxy derivative (100% e.e) by the activated immobilized conidia of Aspergillus ochraceus TS. The immobilized preparation retained 79% of free conidial activity. The immobilized conidia, activated by nutrients, exhibited an increase in 11alpha-hydroxylation, and it was free of the side product 6beta, 11alpha-dihydroxy progesterone. The half life and turnover of immobilized and activated immobilized conidia were 14 and 12 days and 187 and 416 micromoles of the product/g of conidia respectively. The pH and temperature profiles of the free conidia remained unaltered after immobilization and activation. Some germination of conidia inside the matrix owing to incubation with nutrients was detected by scanning electron microscopy.
T K Dutta; T B Samanta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current microbiology     Volume:  39     ISSN:  0343-8651     ISO Abbreviation:  Curr. Microbiol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-24     Completed Date:  2000-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7808448     Medline TA:  Curr Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  309-0312     Citation Subset:  IM    
Marine Biology Institute, 3-75-1 Heita, Kamaishi City, Iwate 026, Japan.
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MeSH Terms
Aspergillus ochraceus / enzymology*
Cells, Immobilized
Cytochrome P-450 Enzyme System*
Glucuronic Acid
Hexuronic Acids
Hydrogen-Ion Concentration
Hydroxyprogesterones / metabolism
Microscopy, Electron, Scanning
Progesterone / metabolism*
Steroid Hydroxylases / metabolism*
Reg. No./Substance:
0/Alginates; 0/Hexuronic Acids; 0/Hydroxyprogesterones; 312-90-3/11-hydroxyprogesterone; 57-83-0/Progesterone; 576-37-4/Glucuronic Acid; 9005-32-7/alginic acid; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.-/Steroid Hydroxylases; EC 1.14.99.-/steroid 11-alpha-hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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