| Bioconversion of dietary provitamin A carotenoids to vitamin A in humans. | |
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MedLine Citation:
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PMID: 20200262 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent progress in the measurement of the bioconversion of dietary provitamin A carotenoids to vitamin A is reviewed in this article. Methods to assess the bioavailability and bioconversion of provitamin A carotenoids have advanced significantly in the past 10 y, specifically through the use of stable isotope methodology, which includes the use of labeled plant foods. The effects of the food matrix on the bioconversion of provitamin A carotenoids to vitamin A, dietary fat effects, and the effect of genotype on the absorption and metabolism of beta-carotene have been reported recently. A summary of the major human studies that determined conversion factors for dietary beta-carotene to retinol is presented here, and these data show that the conversion efficiency of dietary beta-carotene to retinol is in the range of 3.6-28:1 by weight. There is a wide variation in conversion factors reported not only between different studies but also between individuals in a particular study. These findings show that the vitamin A value of individual plant foods rich in provitamin A carotenoids may vary significantly and need further investigation. |
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Authors:
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Guangwen Tang |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-03-03 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 91 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-05-28 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1468S-1473S Citation Subset: AIM; IM |
Affiliation:
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Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. guangwen.tang@tufts.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biotransformation Carotenoids / adverse effects, metabolism* Cell Differentiation Cooking Daucus carota / metabolism Diet Embryonic Development / physiology Female Fruit Humans Intestinal Absorption Male Oryza sativa Spinacia oleracea / metabolism Vegetables Vitamin A / blood, metabolism* Vitamin A Deficiency / drug therapy beta Carotene / metabolism, therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
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DK620021/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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11103-57-4/Vitamin A; 36-88-4/Carotenoids; 7235-40-7/beta Carotene |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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