Document Detail


Bioconversion of dietary provitamin A carotenoids to vitamin A in humans.
MedLine Citation:
PMID:  20200262     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent progress in the measurement of the bioconversion of dietary provitamin A carotenoids to vitamin A is reviewed in this article. Methods to assess the bioavailability and bioconversion of provitamin A carotenoids have advanced significantly in the past 10 y, specifically through the use of stable isotope methodology, which includes the use of labeled plant foods. The effects of the food matrix on the bioconversion of provitamin A carotenoids to vitamin A, dietary fat effects, and the effect of genotype on the absorption and metabolism of beta-carotene have been reported recently. A summary of the major human studies that determined conversion factors for dietary beta-carotene to retinol is presented here, and these data show that the conversion efficiency of dietary beta-carotene to retinol is in the range of 3.6-28:1 by weight. There is a wide variation in conversion factors reported not only between different studies but also between individuals in a particular study. These findings show that the vitamin A value of individual plant foods rich in provitamin A carotenoids may vary significantly and need further investigation.
Authors:
Guangwen Tang
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-03-03
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  91     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-05-28     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1468S-1473S     Citation Subset:  AIM; IM    
Affiliation:
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. guangwen.tang@tufts.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Biotransformation
Carotenoids / adverse effects,  metabolism*
Cell Differentiation
Cooking
Daucus carota / metabolism
Diet
Embryonic Development / physiology
Female
Fruit
Humans
Intestinal Absorption
Male
Oryza sativa
Spinacia oleracea / metabolism
Vegetables
Vitamin A / blood,  metabolism*
Vitamin A Deficiency / drug therapy
beta Carotene / metabolism,  therapeutic use
Grant Support
ID/Acronym/Agency:
DK620021/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
11103-57-4/Vitamin A; 36-88-4/Carotenoids; 7235-40-7/beta Carotene
Comments/Corrections

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