Document Detail

Bioconcentration of lipophilic organochlorines in ovine dentine.
MedLine Citation:
PMID:  11684030     Owner:  NLM     Status:  MEDLINE    
The bioconcentration of lipophilic organochlorines in ovine dentine in comparison to adipose tissue was examined. Sheep were given a single dose (0.2-1.4 mg/kg body wt) of individual polychlorobiphenyl (PCB) congeners (tetrachlorobiphenyls IUPAC Nos. 54 and 80, and hexachlorobiphenyls IUPAC Nos. 155 and 169) and organochlorine pesticides 1,1-bis(4-chlorophenyl)-2,2-dichloroethene) (4,4'-DDE) and hexachlorobenzene (HCB). They were killed 2 months after the dose and teeth and adipose tissue were collected. For the extraction of organochlorines, dentine was treated ultrasonically with sulfuric acid and hexane. The concentration of organochlorines in dentine and adipose tissue was determined by high-resolution gas chromatography with electron-capture detection. The bioconcentration of 'planar' compounds (PCB-169, HCB) in dentine, compared to adipose tissue, was lower than that of 'non-planar' (PCB-155, 4,4'-DDE). Ratios of the non-planar to planar compounds PCB-155/-169 and 4,4'-DDE/HCB in dentine were 1.4 and 7.2, and in adipose tissue 0.5 and 2.4, respectively. The dentine:adipose tissue bioconcentration ratios (on a lipid basis) of PCB-54, -80, -155, -169, 4,4'-DDE and HCB were 47, 16, 0.3, 0.1, 3.2 and 1.0, respectively. The results indicate that the bioconcentration of organochlorines in different tissues cannot be based on lipid content only. It is suggested that the physicochemical properties of individual organochlorines, i.e. lipophilicity (K(ow)), diffusivity, metabolism and tissue-specific interactions, play a part in the different bioconcentrations of individual organochlorine pollutants in dentine compared to adipose tissue.
J Jan; M Vrecl; A Pogacnik; D Gaspersic
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of oral biology     Volume:  46     ISSN:  0003-9969     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-10-30     Completed Date:  2002-01-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1111-6     Citation Subset:  D; IM    
Division of Stomatology, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000, Ljubljana, Slovenia.
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MeSH Terms
Adipose Tissue / metabolism
Body Burden
Dentin / metabolism*
Dichlorodiphenyl Dichloroethylene / pharmacokinetics
Environmental Pollutants / pharmacokinetics*
Hexachlorobenzene / pharmacokinetics
Insecticides / pharmacokinetics*
Polychlorinated Biphenyls / pharmacokinetics*
Tissue Distribution
Reg. No./Substance:
0/Environmental Pollutants; 0/Insecticides; 0/Polychlorinated Biphenyls; 118-74-1/Hexachlorobenzene; 72-55-9/Dichlorodiphenyl Dichloroethylene

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