Document Detail

Bioconcentration, biomagnification and metabolism of 14C-terbutryn and 14C-benzo[a]pyrene in Gammarus fossarum and Asellus aquaticus.
MedLine Citation:
PMID:  16997349     Owner:  NLM     Status:  MEDLINE    
The contribution of bioconcentration and biomagnification of 14C-terbutryn and 14C-benzo[a]pyrene via food and water to the bioaccumulation in Gammarus fossarum and Asellus aquaticus was investigated in single species-tests. In this investigation the uptake of 14C-terbutryn and 14C-benzo[a]pyrene via food and water by G. fossarum (L.) and A. aquaticus (L.) was examined. Bioconcentration factors (BCFs) and biomagnification factors (BMFs) were determined. Calculated BCFs were clearly higher than BMFs, indicating that water is the primary route of uptake. The uptake of terbutryn and benzo[a]pyren via water in G. fossarum and A. aquaticus is faster than uptake via food. The elimination and metabolism of the two chemicals by G. fossarum and A. aquaticus were studied. Terbutryn was eliminated almost completely in both species. In general, the elimination of terbutryn from G. fossarum and A. aquaticus was fast with half-life of 5 h. The elimination of terbutryn by G. fossarum after biomagnification is slower than after bioconcentration. No difference was found in elimination of terbutryn by A. aquaticus after biomagnification and after bioconcentration. Metabolites of terbutryn in G. fossarum and A. aquaticus were analyzed by HPLC. After the bioconcentration experiment a higher percentage of metabolites was found in G. fossarum than in A. aquaticus. This was confirmed for the experiment with uptake via food. The spectrum of metabolites was similar in both species, with hydroxyterbutryn being the major metabolism product in water. 14C-B[a]P could nearly completely be eliminated by G. fossarum (rest of activity 2%) after uptake via water. 14C-B[a]P could not be eliminated by G. fossarum and A. aquaticus after uptake via food. The metabolite could not be identified.
S Richter; R Nagel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-25
Journal Detail:
Title:  Chemosphere     Volume:  66     ISSN:  0045-6535     ISO Abbreviation:  Chemosphere     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-11-28     Completed Date:  2007-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  603-10     Citation Subset:  IM    
TU Dresden, Institut of Zoology, D-01062 Dresden, Germany.
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MeSH Terms
Benzo(a)pyrene / metabolism*,  pharmacokinetics
Chromatography, High Pressure Liquid
Food Contamination
Herbicides / metabolism*,  pharmacokinetics
Triazines / metabolism*,  pharmacokinetics
Water Pollutants, Chemical / metabolism*
Reg. No./Substance:
0/Herbicides; 0/Triazines; 0/Water Pollutants, Chemical; 50-32-8/Benzo(a)pyrene; 886-50-0/terbutryne

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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