| Biocompatible inorganic nanoparticles for [(18)F]-fluoride binding with applications in PET imaging. | |
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MedLine Citation:
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PMID: 21394352 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A wide selection of insoluble nanoparticulate metal salts was screened for avid binding of [(18)F]-fluoride. Hydroxyapatite and aluminium hydroxide nanoparticles showed particularly avid and stable binding of [(18)F]-fluoride in various biological media. The in vivo behaviour of the [(18)F]-labelled hydroxyapatite and aluminium hydroxide particles was determined by PET-CT imaging in mice. [(18)F]-labelled hydroxyapatite was stable in circulation and when trapped in various tissues (lung embolisation, subcutaneous and intramuscular), but accumulation in liver via reticuloendothelial clearance was followed by gradual degradation and release of [(18)F]-fluoride (over a period of 4 h) which accumulated in bone. [(18)F]-labelled aluminium hydroxide was also cleared to liver and spleen but degraded slightly even without liver uptake (subcutanenous and intramuscular). Both materials have properties that are an attractive basis for the design of molecular targeted PET imaging agents labelled with (18)F. |
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Authors:
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Maite Jauregui-Osoro; Peter A Williamson; Arnaud Glaria; Kavitha Sunassee; Putthiporn Charoenphun; Mark A Green; Gregory E D Mullen; Philip J Blower |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-11 |
Journal Detail:
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Title: Dalton transactions (Cambridge, England : 2003) Volume: - ISSN: 1477-9234 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101176026 Medline TA: Dalton Trans Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Imaging Sciences, King's College London, St. Thomas' Hospital, London, UKSE1 7EH. Philip.Blower@kcl.ac.uk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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