Document Detail


Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity.
MedLine Citation:
PMID:  20377197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Excitement surrounding the attractive physical and chemical characteristics of single walled carbon nanotubes (SWCNTs) has been tempered by concerns regarding their potential health risks. Here we consider the lung toxicity of nanoscale dispersed SWCNTs (mean diameter approximately 1 nm). Because dispersion of the SWCNTs increases their aspect ratio relative to as-produced aggregates, we directly test the prevailing hypothesis that lung toxicity associated with SWCNTs compared with other carbon structures is attributable to the large aspect ratio of the individual particles. Thirty days after their intratracheal administration to mice, the granuloma-like structures with mild fibrosis in the large airways observed in mice treated with aggregated SWCNTs were absent in mice treated with nanoscale dispersed SWCNTs. Examination of lung sections from mice treated with nanoscale dispersed SWCNTs revealed uptake of the SWCNTs by macrophages and gradual clearance over time. We conclude that the toxicity of SWCNTs in vivo is attributable to aggregation of the nanomaterial rather than the large aspect ratio of the individual nanotubes. Biocompatible nanoscale dispersion provides a scalable method to generate purified preparations of SWCNTs with minimal toxicity, thus allowing them to be used safely in commercial and biomedical applications.
Authors:
Gökhan M Mutlu; G R Scott Budinger; Alexander A Green; Daniela Urich; Saul Soberanes; Sergio E Chiarella; George F Alheid; Donald R McCrimmon; Igal Szleifer; Mark C Hersam
Related Documents :
23801067 - Transgenic mice for cgmp imaging.
23169997 - Interaction of lipocalin 2, transferrin, and siderophores determines the replicative ni...
23355887 - Inflammation subverts hippocampal synaptic plasticity in experimental multiple sclerosis.
24621517 - Salusin-β not salusin-α promotes vascular inflammation in apoe-deficient mice via the...
12120037 - Light and ultrastructural study of sciatic nerve lesions induced using intraneural inje...
23801067 - Transgenic mice for cgmp imaging.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Nano letters     Volume:  10     ISSN:  1530-6992     ISO Abbreviation:  Nano Lett.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-13     Completed Date:  2010-09-13     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  101088070     Medline TA:  Nano Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1664-70     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials / toxicity*
Colloids / chemistry,  toxicity
Crystallization / methods
Materials Testing
Mice
Mice, Inbred C57BL
Nanotubes / chemistry*,  toxicity*,  ultrastructure
Particle Size
Trachea / drug effects*,  pathology*
Tracheitis / chemically induced*,  pathology*
Grant Support
ID/Acronym/Agency:
ES013995/ES/NIEHS NIH HHS; ES015024/ES/NIEHS NIH HHS; HL067835/HL/NHLBI NIH HHS; HL071643/HL/NHLBI NIH HHS; K08 HL067835/HL/NHLBI NIH HHS; K08 HL067835-01/HL/NHLBI NIH HHS; P01 HL071643/HL/NHLBI NIH HHS; P01 HL071643-01A1/HL/NHLBI NIH HHS; P30 CA060553/CA/NCI NIH HHS; R01 ES013995/ES/NIEHS NIH HHS; R01 ES013995-01A1/ES/NIEHS NIH HHS; R01 ES015024/ES/NIEHS NIH HHS; R01 ES015024-01/ES/NIEHS NIH HHS; R01 HL088580/HL/NHLBI NIH HHS; UL1 RR025741/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Colloids
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gate-defined graphene double quantum dot and excited state spectroscopy.
Next Document:  Large, Solution-Processable Graphene Quantum Dots as Light Absorbers for Photovoltaics.