Document Detail


Biocompatible Carbon Nanotube - Chitosan Cardiac Scaffold Matching the Electrical Conductivity of the Heart.
MedLine Citation:
PMID:  25233037     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The major limitation of current engineered myocardial patches for the repair of heart defects is that insulating polymeric scaffold walls hinder the transfer of electrical signals between cardiomyocytes. This loss in signal transduction results in arrhythmias when the scaffolds are implanted. We report that small, sub-toxic, concentrations of single-walled carbon nanotubes (SWNTs), on the order of ten parts per million (ppm), incorporated in a gelatin-chitosan hydrogel act as electrical nano-bridges between cardiomyocytes, resulting in enhanced electrical coupling, synchronous beating and cardiomyocyte function. These engineered tissues achieve excitation conduction velocities similar to native myocardial tissue (22 ± 9 cm/s) and could function as a full-thickness patch for several cardiovascular defect repair procedures, such as right ventricular outflow track (RVOT) repair for Tetralogy of Fallot, atrial and ventricular septal defect repair and other cardiac defects, without the risk of inducing cardiac arrhythmias.
Authors:
Seokwon Pok; Flavia Vitale; Shannon L Eichmann; Omar M Benavides; Matteo Pasquali; Jeffrey G Jacot
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-18
Journal Detail:
Title:  ACS nano     Volume:  -     ISSN:  1936-086X     ISO Abbreviation:  ACS Nano     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101313589     Medline TA:  ACS Nano     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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