Document Detail

Biocompatibility studies on peritoneal cells.
MedLine Citation:
PMID:  7948270     Owner:  NLM     Status:  MEDLINE    
This review outlines the problems involved in assessing the biocompatibility of PD fluids. It has summarized the data available from conventional in vitro studies and highlights many of the inadequacies of this approach. In vivo data are lacking both on host defense and on the clinical effect of changing conventional PD fluids for a more "ideal" formulation. The best parameters for assessing biocompatibility need to be defined. Alternative formulation of fluids must be aimed towards (1) a system that interferes minimally with host defense, and (2) a system that maintains the integrity of the peritoneal membrane for ultrafiltration and clearance. Cell culture studies should be designed to model the in vivo situation. Ex vivo studies (cells exposed within the peritoneal cavity) should be used to support in vivo findings. Finally, in vitro results must be related to clinical significance, and changes in fluid composition should be followed by improvements in clinical outcome.
N Topley; G A Coles; J D Williams
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  14 Suppl 3     ISSN:  0896-8608     ISO Abbreviation:  Perit Dial Int     Publication Date:  1994  
Date Detail:
Created Date:  1994-12-28     Completed Date:  1994-12-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  S21-8     Citation Subset:  IM    
Institute of Nephrology, University of Wales College of Medicine, Cardiff Royal Infirmary, United Kingdom.
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MeSH Terms
Biocompatible Materials*
Dialysis Solutions* / toxicity
Peritoneal Cavity / cytology
Peritoneal Dialysis, Continuous Ambulatory*
Peritoneum / drug effects*
Toxicity Tests
Reg. No./Substance:
0/Biocompatible Materials; 0/Dialysis Solutions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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