Document Detail

Biocompatibility and resorbability of a polylactic acid membrane for periodontal guided tissue regeneration.
MedLine Citation:
PMID:  8507778     Owner:  NLM     Status:  MEDLINE    
The biocompatibility and degradation processes of biomembranes made of a mixture of a high molecular weight racemic polylactic acid (PLA50P) with 0, 10, 20 and 30% w/w racemic polylactic acid oligomers (PLA50p) were assessed for morphological changes in subcutaneous abdominal membrane implantations after 15, 21, 30 and 60 d in 45 Wistar rats. These membranes, prepared for periodontal guided tissue regeneration, showed excellent tissue tolerance without an inflammatory reaction. The higher the content in low molecular weight polylactic acid, the higher the degradation rate. At 60 d, the resorption process was almost complete. This process was initiated by outgrowths of short vascular septa, which developed into lobular networks infiltrating the membranes, which were progressively replaced by normal fibrous connective tissue.
P Robert; J Mauduit; R M Frank; M Vert
Related Documents :
19190678 - Increased tissue acid mediates a progressive decline in the glomerular filtration rate ...
21954318 - Biophysical investigations into the interactions of endotoxins with bile acids.
10022638 - Fat intake and fatty acid profile in plasma phospholipids and adipose tissue in patient...
21265538 - A general procedure for the synthesis of enones via gold-catalyzed meyer-schuster rearr...
6314948 - Chemical composition of human bone.
11394258 - Extracellular ph defense against lactic acid in normoxia and hypoxia before and after a...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomaterials     Volume:  14     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-07-15     Completed Date:  1993-07-15     Revised Date:  2006-04-17    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  353-8     Citation Subset:  IM    
Centre de Recherches, Faculté de Chirurgie Dentaire, Strasbourg, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biocompatible Materials*
Guided Tissue Regeneration, Periodontal*
Lactates / chemistry*
Lactic Acid*
Membranes, Artificial*
Molecular Weight
Polymers / chemistry*
Rats, Wistar
Reg. No./Substance:
0/Biocompatible Materials; 0/Lactates; 0/Membranes, Artificial; 0/Polymers; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Erosion and compressive strength of hybrid glass ionomer cements when light activated or chemically ...
Next Document:  In vitro evaluation of cell/biomaterial interaction by MTT assay.