Document Detail


Biocompatibility and resorbability of a polylactic acid membrane for periodontal guided tissue regeneration.
MedLine Citation:
PMID:  8507778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The biocompatibility and degradation processes of biomembranes made of a mixture of a high molecular weight racemic polylactic acid (PLA50P) with 0, 10, 20 and 30% w/w racemic polylactic acid oligomers (PLA50p) were assessed for morphological changes in subcutaneous abdominal membrane implantations after 15, 21, 30 and 60 d in 45 Wistar rats. These membranes, prepared for periodontal guided tissue regeneration, showed excellent tissue tolerance without an inflammatory reaction. The higher the content in low molecular weight polylactic acid, the higher the degradation rate. At 60 d, the resorption process was almost complete. This process was initiated by outgrowths of short vascular septa, which developed into lobular networks infiltrating the membranes, which were progressively replaced by normal fibrous connective tissue.
Authors:
P Robert; J Mauduit; R M Frank; M Vert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomaterials     Volume:  14     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-07-15     Completed Date:  1993-07-15     Revised Date:  2006-04-17    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  353-8     Citation Subset:  IM    
Affiliation:
Centre de Recherches, Faculté de Chirurgie Dentaire, Strasbourg, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials*
Guided Tissue Regeneration, Periodontal*
Lactates / chemistry*
Lactic Acid*
Membranes, Artificial*
Molecular Weight
Polymers / chemistry*
Rats
Rats, Wistar
Stereoisomerism
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Lactates; 0/Membranes, Artificial; 0/Polymers; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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