Document Detail

Biocompatibility of peritoneal dialysis fluid and influence of compositions on peritoneal fibrosis.
MedLine Citation:
PMID:  16911191     Owner:  NLM     Status:  MEDLINE    
Conventional peritoneal dialysis fluid (PDF) is a bioincompatible solution because of several components. These unphysiological compositions might contribute to the development of peritoneal fibrosis. In the present overview we summarize the influence of each composition of PDF (acidic pH, high concentration of glucose and glucose degradation products; advanced glycation end-products and lactate) on the peritoneal fibrotic changes in long peritoneal dialysis (PD) patients. We also summarized the report of new approaches to the prevention of peritoneal fibrosis in Japan.
Chieko Higuchi; Hideki Nishimura; Tsutomu Sanaka
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy     Volume:  10     ISSN:  1744-9979     ISO Abbreviation:  Ther Apher Dial     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-16     Completed Date:  2007-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181252     Medline TA:  Ther Apher Dial     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  372-9     Citation Subset:  IM    
Division of Internal Medicine, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
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MeSH Terms
Biocompatible Materials / adverse effects*,  chemistry
Dialysis Solutions / adverse effects*,  chemistry
Fibrosis / chemically induced
Glucose / adverse effects
Glycosylation End Products, Advanced / metabolism
Hydrogen-Ion Concentration
Kidney Failure, Chronic / pathology*,  therapy*
Lactic Acid / metabolism
Peritoneal Dialysis / adverse effects*
Peritoneum / pathology*
Reg. No./Substance:
0/Biocompatible Materials; 0/Dialysis Solutions; 0/Glycosylation End Products, Advanced; 50-21-5/Lactic Acid; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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