Document Detail

Biocompatibility and osteogenic potential of new generation endodontic materials established by using primary osteoblasts.
MedLine Citation:
PMID:  21763915     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: Generex A and Generex B (calcium silicate based), Capasio (calcium-phospho-alumino silicate based) along with Ceramicrete-D (magnesium phosphate based) are being introduced as a new generation of endodontic materials with the potential to facilitate bone healing. The aim of this study was to evaluate the biocompatibility and osteogenic potential of these new materials by using primary osteoblasts.
METHODS: Primary osteoblasts were prepared from rat calvaria and exposed to mineral trioxide aggregate (MTA), Generex A, Generex B, Capasio, and Ceramicrete-D prepared to standardized size and shape (n = 5). Trypan blue staining was used to evaluate cell viability from 1-6 days. Mineralization potential was evaluated by scanning electron microscopy for the presence of mineralized nodules. Data were analyzed by Kruskal-Wallis and Mann-Whitney U tests.
RESULTS: Only Generex A and MTA allowed cell growth and proliferation throughout the experiment. There were statistically significant differences between groups throughout the experiment beginning on day 1. The greatest amount of cell growth was consistently observed with Generex A and MTA. There was no difference in mineralized nodule formation between any test materials.
CONCLUSIONS: Generex A was the only new generation endodontic material that supported primary osteoblast growth; no material besides MTA facilitated nodule formation.
Jelani T Washington; Emet Schneiderman; Robert Spears; Claudia R Fernandez; Jianing He; Lynne A Opperman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of endodontics     Volume:  37     ISSN:  1878-3554     ISO Abbreviation:  J Endod     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7511484     Medline TA:  J Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1166-70     Citation Subset:  D    
Copyright Information:
Copyright © 2011 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
Department of Endodontics, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, Texas; Private Practice, Richardson, Texas.
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