Document Detail


Biocompatibility of dialysis membranes: effects of chronic complement activation.
MedLine Citation:
PMID:  6334194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of three dialysis membranes (cuprophane, cellulose acetate, and polymethylmethacrylate) to activate complement was studied prospectively in ten chronic dialysis patients using new and reused membranes. Patients were dialyzed for 1 month with each type of membrane. New cuprophane membranes caused the most intense activation, while polymethylmethacrylate (PMMA) surfaces caused the least degree of complement activation. Reuse decreases the capacity of the cuprophane membrane to activate complement but does not significantly alter the capacity of cellulose acetate membranes. The extent of complement activation paralleled the ability of these membranes to induce neutropenia. Recurrent dialysis with new cuprophane and cellulose acetate membranes leads to a decrease in pre-dialysis and "rebound leukocytosis" neutrophil count, as well as a more intense activation of complement and an enhanced endogenous clearance of products of complement activation. The clinical sequelae of recurrent complement activation are discussed.
Authors:
R M Hakim; D T Fearon; J M Lazarus
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Kidney international     Volume:  26     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1985-01-03     Completed Date:  1985-01-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  194-200     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biocompatible Materials / pharmacology*
Cellulose / analogs & derivatives,  pharmacology
Complement Activation / drug effects*
Complement C3 / metabolism
Complement C3a
Humans
Kidney Failure, Chronic / immunology*
Leukocyte Count
Membranes, Artificial
Methylmethacrylates / pharmacology
Neutrophils / drug effects
Renal Dialysis*
Time Factors
Grant Support
ID/Acronym/Agency:
AI-10356/AI/NIAID NIH HHS; AI-17917/AI/NIAID NIH HHS; HL-27041/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Complement C3; 0/Membranes, Artificial; 0/Methylmethacrylates; 80295-42-7/Complement C3a; 9004-34-6/Cellulose; 9004-35-7/acetylcellulose; 9050-09-3/cuprammonium cellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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