Document Detail

Biocompatibility of New Calcium Aluminate Cement (EndoBinder).
MedLine Citation:
PMID:  22341076     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: The purpose of this study was to evaluate the biocompatibility of calcium aluminate cement (EndoBinder) in subcutaneous tissue of rats.
METHODS: Fifteen rats, weighing 300 g, were separated into 3 groups (n = 5) in accordance with the time of death (7, 21, 42 days). Two incisions were made in the dorsal subcutaneous tissue of each rat in which were implanted 2 polyethylene tubes filled with the test materials, EndoBinder (EB) and Grey MTA (GMTA). The external tube walls were considered the negative control group (CG). After 7, 21, and 42 days, animals were killed, obtaining 5 samples per group, at each time interval of analysis.
RESULTS: From the morphologic and morphometric analyses by using a score of (0-3) (50, 100, and 400×), results showed absence of inflammatory reaction (0) for EB after 42 days. However, for GMTA, a slight inflammatory reaction (1) was observed after 42 days, which means the persistence of a chronic inflammatory process. When compared with CG, tissue reaction ranging from discrete (1-7 days) to absent (0-42 days) was observed.
CONCLUSIONS: EndoBinder presented satisfactory tissue reaction; it was biocompatible when tested in subcutaneous tissue of rats.
Fabiano Gamero Aguilar; Lucas Fonseca Roberti Garcia; Fernanda Carvalho Panzeri Pires-de-Souza
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Publication Detail:
Type:  Journal Article     Date:  2011-12-24
Journal Detail:
Title:  Journal of endodontics     Volume:  38     ISSN:  1878-3554     ISO Abbreviation:  J Endod     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7511484     Medline TA:  J Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  367-71     Citation Subset:  D    
Copyright Information:
Copyright © 2012 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
Department of Dental Materials and Prosthodontics, Ribeirão Preto School of Dentistry, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
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