Document Detail


Biocompatibility and Inflammation Profile of B2A-Coated Granules Used in Arthrodesis.
MedLine Citation:
PMID:  23422080     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The biocompatibility/inflammation profile of B2A-coated ceramic granules was evaluated using a panel of standard biocompatibility protocols (International Organization for Standardization-10993) including skin irritation and delayed-type hypersensitivity (Kligman maximization test), as well as acute, subacute, and chronic toxicity. Additionally, the potential of B2A-coated granules to elicit inflammatory reactions was also assessed using in vivo air pouch models, and B2A was evaluated using in vitro models of leukocyte recruitment and endothelial cell activation. Overall, the findings demonstrate that B2A-coated ceramic granules exhibit good biocompatibility profiles in the murine air pouch model and in standard subcutaneous implant models, and B2A did not demonstrate evidence of leukocyte recruitment or endothelial cell activation. These findings suggest that B2A and B2A-coated granules have little, if any, propensity to initiate inflammation reactions based on leukocyte recruitment. Thus, traditional biocompatibility and specially designed inflammation models indicate a high degree of biocompatibility and a low possibility of toxicity, inflammation, or edema following the implant of B2A-coated granules.
Authors:
Paul O Zamora; Yi Liu; Henry Guo; Xinhua Lin
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-19
Journal Detail:
Title:  International journal of toxicology     Volume:  -     ISSN:  1092-874X     ISO Abbreviation:  Int. J. Toxicol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708436     Medline TA:  Int J Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
MD, USA.
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