Document Detail

Biocompatibility of 1-French polyethylene catheters used in interventional neuroradiology procedures: a study with rats and dogs.
MedLine Citation:
PMID:  2120990     Owner:  NLM     Status:  MEDLINE    
This study was designed to investigate the thrombogenicity, inflammatory response, and endothelial response to the presence of sterilized, 1-French polyethylene catheters implanted into the arterial system and subcutaneous tissues of 18 rats and two dogs. At time periods ranging from 1 week to 6 months, repeat angiography was done, the animals sacrificed, and the tissues containing the catheter removed for histologic study. In the subcutaneous tissues the catheter became encased in a very thin (less than 0.5 mm) coating of fibrous tissue with no evidence of inflammation. In large vessels, the catheter at all time periods appeared identical both angiographically and histologically to that at the time of implantation. In small to medium-sized vessels a slight increase in vessel size (25% increase in diameter of the rat iliac) was observed angiographically. On histologic evaluation, there was evidence of myointimal hypertrophy, which was asymmetrically placed, centered around the position of the catheter. There was no evidence of thrombi or of incorporation of the catheter itself into the hypertrophic tissue. In dogs and rats, an implanted 1-French polyethylene catheter is well tolerated: the animals showed no evidence of thrombotic, thromboembolic, or inflammatory complications. Myointimal hypertrophy was observed in small to medium-sized arteries, which is of unknown significance.
C R Partington; V B Graves; D A Rüfenacht; C M Strother; A H Rappe; J J Merland; A Laurent
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  11     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:    1990 Sep-Oct
Date Detail:
Created Date:  1990-11-16     Completed Date:  1990-11-16     Revised Date:  2008-02-14    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  881-5     Citation Subset:  IM    
Department of Radiology, University of Wisconsin, Madison 53792.
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MeSH Terms
Arteries / pathology
Biocompatible Materials*
Carotid Artery Thrombosis / pathology
Catheters, Indwelling*
Nervous System / blood supply,  radiography*
Radiography, Interventional*
Time Factors
Reg. No./Substance:
0/Biocompatible Materials; 0/Polyethylenes

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