Document Detail

Biochemistry and the schizophrenias.
MedLine Citation:
PMID:  39348     Owner:  NLM     Status:  MEDLINE    
This paper reviews the present status of the transmethylation and the dopamine hypotheses of schizophrenia and presents recent data on the definitive identification and measurement of the endogenous hallucinogen, dimethyltryptamine (DMT) in human cerebrospinal fluid and urine. Elevated levels are found in some cases of schizophrenia and of liver disease. Evidence is discussed showing that DMT may be a normal neuroregulatory agent which is responsive to stress or emotional reactions.
J R Smythies
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  72     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1979-11-29     Completed Date:  1979-11-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1272-6     Citation Subset:  AIM; IM    
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MeSH Terms
Dopamine / metabolism
Methionine / metabolism
N,N-Dimethyltryptamine / cerebrospinal fluid
Neurotransmitter Agents / cerebrospinal fluid,  physiology
Schizophrenia / metabolism*,  physiopathology
Reg. No./Substance:
0/Neurotransmitter Agents; 61-50-7/N,N-Dimethyltryptamine; 63-68-3/Methionine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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