Document Detail

Biochemistry in diagnosis and management of abnormal early pregnancy.
MedLine Citation:
PMID:  15232489     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: This review examines the biochemical parameters of early pregnancy failure and the role that biochemical markers have to play in the selection of patients for expectant management. RECENT FINDINGS: Earlier studies have concentrated on the role that human chorionic gonadotrophin and progesterone have to play in early pregnancy failure. Recent studies, however, have explored newer markers such as the inhibins and insulin growth factor binding proteins. Diagnostic models have now been created incorporating demographic, morphological, and biochemical parameters for the prediction of successful expectant management of early pregnancy failure. SUMMARY: Examining the role of newer biochemical markers in early pregnancy failure has led to an improved understanding of the mechanisms behind it. Incorporation of these newer markers into diagnostic models has aided selection of patients for whom expectant management is appropriate.
Janine Elson; Davor Jurkovic
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  16     ISSN:  1040-872X     ISO Abbreviation:  Curr. Opin. Obstet. Gynecol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-02     Completed Date:  2004-12-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  339-44     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Lippincott Williams and Wilkins
Early Pregnancy Assessment Unit, Kings College Hospital, Denmark Hill, London, UK.
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MeSH Terms
17-alpha-Hydroxyprogesterone / metabolism
Abortion, Spontaneous / diagnosis,  metabolism*,  prevention & control
Biological Markers / analysis*
Chorionic Gonadotropin / metabolism
Inhibins / metabolism
Insulin-Like Growth Factor Binding Protein 1 / metabolism
Pregnancy Outcome
Progesterone / metabolism
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin; 0/Insulin-Like Growth Factor Binding Protein 1; 0/inhibin A; 57-83-0/Progesterone; 57285-09-3/Inhibins; 68-96-2/17-alpha-Hydroxyprogesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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