Document Detail

Biochemistry of aromatase: significance to female reproductive physiology.
MedLine Citation:
PMID:  7083198     Owner:  NLM     Status:  MEDLINE    
The formation of estrogens in mammals via aromatase involves the relatively unique capacity to form an aromatic ring de novo in contrast to most other aromatic substances (essential amino acids) which are obtained only in the diet. The reaction is the only example of a cytochrome P450 system which resides in both the mitochondrial and microsomal fractions of the cell. It occurs widely throughout the body in diverse tissues and functions via both de novo synthesis and transformation of prehormones (androstenedione and testosterone). It is found widely in animal species in both the brain and gonads even in phylogenetically primitive species. Placental aromatase appears to be associated with the evolution of viviparity and an extended gestational period in utero. Follicular aromatase which is dependent upon follicle-stimulating hormone stimulation appears to be essential for oogenesis, ovulation, and normal luteal functions while central nervous system aromatase serves to determine sexual behavior and the neurohormonal link to the hypothalamus and pituitary for ovarian cyclicity. While estrogens are the key to pituitary, breast, and endometrial growth and development, this hormone is one of the few examples of an endogenous steroid that has been implicated as a carcinogen or a stimulant for carcinogenesis.
K J Ryan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer research     Volume:  42     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-08-26     Completed Date:  1982-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3342s-3344s     Citation Subset:  IM    
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MeSH Terms
Aromatase / metabolism*
Brain / enzymology
Breast / enzymology
Estrogens / biosynthesis*
Ovary / enzymology*
Oxidoreductases / metabolism*
Placenta / enzymology
Reg. No./Substance:
0/Estrogens; EC 1.-/Oxidoreductases; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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