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Biochemical and toxicological response of infant baboons to lead driers in paint.
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MedLine Citation:
PMID:  4208656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In an effort to define the toxicology and disposition of lead compounds that presently exist in paint (i.e., organic driers), a controlled dose feeding study was initiated early this year with the use of 28 infant baboons as experimental animals. The infant baboon, established as a metabolic model for a child ingesting lead, will be used to determine the adequacy of present as well as recently recommended limitations for lead in paint to assure protection from this potential source of lead exposure. To accomplish this goal, research has been designed to determine basic dose-response relationships in animals ingesting constant daily doses of a dried paint, a lead octoate drier, and lead acetate. Doses for these compounds have been chosen to cover a broad range of concentrations including that recommended by the American Academy of Pediatrics from the maximum daily permissible lead ingestion, and associated estimates of paint intake by children with pica. PARAMETERS OF METABOLIC RESPONSE FOR EACH LEAD COMPOUND, INCLUDE: general clinical surveillance, lead concentrations in blood, urine and feces, erythrocytic delta-aminolevulinic acid dehydratase and free erythrocytic porphyrin. The response of several of these measures of lead exposure as a function of time will be discussed for each compound at the several dose levels administered.
Authors:
N Cohen; T J Kneip; V Rulon; D H Goldstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental health perspectives     Volume:  7     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1974 May 
Date Detail:
Created Date:  1974-07-26     Completed Date:  1974-07-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  161-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Disease Models, Animal*
Dose-Response Relationship, Drug
Erythrocytes
Feces / analysis
Haplorhini
Injections, Intravenous
Lead / administration & dosage,  blood,  urine
Lead Poisoning / metabolism*
Levulinic Acids / blood
Maximum Allowable Concentration
Paint / toxicity*
Papio*
Porphobilinogen Synthase / blood
Porphyrins / blood
Spectrophotometry, Atomic
Time Factors
Chemical
Reg. No./Substance:
0/Levulinic Acids; 0/Porphyrins; 7439-92-1/Lead; EC 4.2.1.24/Porphobilinogen Synthase
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 05 Year: 1974
Volume: 7First Page: 161 Last Page: 173
ID: 1475128
PubMed Id: 4208656
PubMed Id: 4208656

Biochemical and Toxicological Response of Infant Baboons to Lead Driers in Paint
Norman Cohen
Theo. J. Kneip
Virginia Rulon
David H. Goldstein



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